Apoptosis in Human Endometrial and Endometriotic Tissues
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Abstract
Apoptosis has recently been proposed to represent programmed cell death. Several investigations have revealed that uterine endometrium in mammals can be regulated by apoptosis. However, apoptosis may be less likely to occur in human eutopic endometrium. On the other hand, immunoreactivity of Bcl-2 that may serve a regulatory function in protecting from undergoing apoptosis was observed in uterine endometrial glandular cells in the proliferative phase through to the early secretory phase. In endometriotic tissues, although apoptosis was detected in all the samples from ovarian endometriosis, it was indicated in only a few tissues from adenomyosis. Bcl-2 was negative in almost all samples from ovarian endometriosis, whereas it was positive in all adenomyotic tissues from cases in the proliferative phase, but in none of tissues from cases in the secretory phase. Thus, ovarian endometriosis can be discriminated from adenomyosis based on the existence of apoptosis though both represent a type of ectopic endometrial tissue, and the pathogenesis or condition of the cells may be different between ovarian endometriosis and adenomyosis.
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Cited by (25)
- Evaluation of apoptosis and angiogenesis in ectopic and eutopic stromal cells of patients with endometriosis compared to non-endometriotic controls 2020
- Influência de agentes antiangiogênicos (propranolol) em endometriose experimentalmente induzida em ratas 2017
- Potential New Drugs for Endometriosis: Experimental Evidence 2014
- Apoptosis through regulation of Bcl-2, Bax and Mcl-1 expressions in endometriotic cyst lesions and the endometrium of women with moderate to severe endometriosis 2013
- Apoptosis Resistance in Endometriosis 2011
- Apoptosis and bcl-2 expression in ectopic endometrium of patient with endometriosis 2011
- Involvement of resistance to apoptosis in the pathogenesis of endometriosis. 2009
- Apoptosis in normal ovaries of women with and without endometriosis 2009
- Transcriptional expression of survivin and its splice variants in endometriosis 2006
- Expression of apoptosis-related proteins in peritoneal, ovarian and colorectal endometriosis 2005
- Reduction of apoptosis and proliferation in endometriosis 2004
- Endometriotic cells are resistant to interferon-γ-induced cell growth inhibition and apoptosis: a possible mechanism involved in the pathogenesis of endometriosis 2004
- Expression of apoptosis-related proteins in endometriomas and benign and malignant ovarian tumours 2003
- Biological Implications of Survivin Gene Expression in the Development of Endometriosis and Endometrial Carcinoma 2003
- Abnormal cervicovaginal smears due to endometriosis: A continuing problem 2002
- Survivin Gene Expression in Endometriosis 2002
- Apoptosis in endometrial glandular and stromal cells in women with and without endometriosis 2001
- Concentration of Nitric Oxide in Chocolate Cyst Fluid 2001
- Increased Insulin-like Growth Factor 1 Activity Can Rescue KLE Endometrial-like Cells from Apoptosis 2001
- Theories of endometriosis 2001
- Effects of the levonorgestrel-releasing intrauterine system on proliferation and apoptosis in the endometrium 2001
- Is endometriosis an endometrial disease? 2000
- Gonadotropin-releasing hormone analog repairs reduced endometrial cell apoptosis in endometriosis in vitro 2000
- Apoptosis and Ki-67 Expression in Adenomyotic Lesions and in the Corresponding Eutopic Endometrium 1999
- Apoptosis and Ki-67 expression in adenomyotic lesions and in the corresponding eutopic endometrium 1999
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- europepmc
- last seen: 2026-06-12T06:13:51.797165+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:10:52.568893+00:00
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