Biological Implications of Survivin Gene Expression in the Development of Endometriosis and Endometrial Carcinoma

Masatsugu Ueda, Yoshiki Yamashita, Mikio Takehara, Yoshito Terai, Koji Kumagai, Ken Ueki, Koji Kanda, Hiroyuki Yamaguchi, Daisuke Akise, Hikari Yamashita, Yao‐Ching Hung, Minoru Ueki
In: Cell and Molecular Biology of Endometrial Carcinoma · 2003 · pp. 252–263 · doi:10.1007/978-4-431-53981-0_18 · W2232508004
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-09 ⓘ

Survivin and MMP gene expression was significantly higher in aggressive endometriosis and endometrial carcinoma tissues, correlating with invasion and lower apoptosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

The study measured mRNA expression of survivin, MMP-2, MMP-9, and MT1-MMP in 63 pigmented or non-pigmented endometriotic tissues, 26 endometrial carcinoma tissues, and 12 normal eutopic endometrial tissues. Survivin and MMP gene expression were significantly higher in clinically aggressive pigmented endometriotic lesions than in normal eutopic endometrium, with higher survivin in pigmented versus non-pigmented lesions, and survivin expression correlated with MMPs across endometriotic samples. Apoptotic cells were rare in 11 ovarian endometriotic tissues that showed positive immunohistochemical staining for survivin and MMPs, and in endometrial carcinoma, survivin and MMP expression were higher than in normal endometrium and correlated with depth of myometrial invasion. The paper does not explicitly discuss a specific limitation, but it relies on tissue expression correlations rather than direct mechanistic testing. This paper is centrally about endometriosis — it examines how survivin and MMP expression patterns in endometriotic lesions relate to survival and invasion.

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endometriosis

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