Transcriptional expression of survivin and its splice variants in endometriosis

Kuniko Fujino, Masatsugu Ueda, Mikio Takehara, Hikari Futakuchi, Koji Kanda, Yoshiki Yamashita, Yoshito Terai, Minoru Ueki
Molecular human reproduction · 2006 · vol. 12(6) , pp. 383–388 · doi:10.1093/molehr/gal042 · PMID:16644787 · W2121838263
article OA: bronze CC0 ⤵ 21 in-corpus citations
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Survivin mRNA expression was significantly higher in ectopic endometriotic tissues than in eutopic endometrium, with increased survivin-EX3/survivin ratios in peritoneal lesions.

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Abstract

Survivin is a novel inhibitor of apoptosis (IAP), and the two splice variants of survivin (survivin-2B and survivin-EX3) have been identified. Gene expression levels of survivin, survivin-2B and survivin-EX3 in 56 ectopic (16 peritoneal red and 16 peritoneal black lesions and 24 ovarian endometriomata) and 13 eutopic endometrial tissues surgically obtained from 42 women with endometriosis (group A) were compared with those in 16 control eutopic endometrium from 16 women without endometriosis (group B) by quantitative RT-PCR analysis. Survivin mRNA expression levels in ectopic endometriotic tissues were significantly higher than those in eutopic endometrium of groups A and B over the whole cycle. Red peritoneal lesions had higher gene expression levels of survivin than black lesions. In contrast, all tissue samples examined showed relatively lower gene expression levels of survivin-2B and survivin-EX3. No cyclic variation was found in survivin and the two splice variants, both in ectopic and in eutopic endometrium. Although there was no significant difference in the ratio of survivin-2B/survivin between ectopic and eutopic endometrium, the ratio of survivin-EX3/survivin in peritoneal endometriotic lesions was significantly higher than that of eutopic endometrium of groups A and B. These results suggest that survivin and survivin-EX3 may be closely linked to escape from apoptosis and the development of endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Gene Expression Microtubule-Associated Proteins Neoplasm Proteins Adult Alternative Splicing Alternative Splicing Endometriosis Endometrium Endometrium Endometrium Female Gene Expression Genetic Variation Genetic Variation Humans Inhibitor of Apoptosis Proteins Microtubule-Associated Proteins Neoplasm Proteins Reverse Transcriptase Polymerase Chain Reaction

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