Faculty Opinions recommendation of A conditionally replicative adenovirus, CRAd-S-pK7, can target endometriosis with a cell-killing effect.

Ricardo Buquet, Edgardo Rolla
In: Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2010 · doi:10.3410/f.4570956.4442054 · W4210713810
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⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

CRAd-S-pK7, a modified adenovirus with a specific promoter and enhanced infectivity, was investigated for its ability to target endometriosis and induce cell killing.

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Abstract

background: Novel therapeutic approaches for endometriosis based on molecular strategies may prove to be useful. Conditionally replicative adenoviruses (CRAds) are designed to exploit key differences between target and normal cells. The wild-type adenovirus (Adwt) promoter can be replaced by tissue-specific promoters, allowing viral replication only in target cells. Viral infectivity can be enhanced by altering Ad tropism via fiber modification. We investigated whether CRAds can be used to target endometriosis and determined the most efficient transcriptional-and transductional-targeting strategy.

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (49)

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