Atypical epithelial changes and mutant p53 gene expression in ovarian endometriosis

Bayramoğlu H, Hatice Bayramođlu, H Bayramoğlu, Düzcan E, E Düzcan, Ender Düzcan
Pathology oncology research : POR · 2001 · vol. 7(1) , pp. 33–38 · doi:10.1007/bf03032602 · PMID:11349218 · W2059375091
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-16 ⓘ

This study evaluated epithelial atypia in ovarian endometriosis and found it in 5.8% of cases, but immunohistochemical p53 expression was not detected in atypical or non-atypical endometriosis samples.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This retrospective study examined 120 histopathologically diagnosed ovarian endometriosis cases and compared them with 10 previously diagnosed ovarian endometrioid carcinomas, totaling 140 samples, to determine the incidence and cytological criteria of atypical endometriosis and assess malignant potential using immunohistochemistry for p53. Atypia was observed in 7 cases (5.8%), reactive atypia in 37 (30.8%), and no atypia in 76 (63.4%), and the authors evaluated epithelial and stromal features and inflammatory cells. p53 immunostaining showed no staining in atypical, reactive atypical, and non-atypical endometriosis cases, while 3 of the endometrioid carcinoma cases were positive; the study also proposes that prominent nucleoli and angulated nuclear contours can be added to criteria of atypia. The paper limits interpretation by concluding that absence of p53 staining does not determine that atypical lesions are not premalignant. This paper is centrally about endometriosis—specifically ovarian endometriosis epithelial atypia and p53 immunohistochemical expression.

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Abstract

It has been reported that cases of ovarian endometriosis those with epithelial cytological atypia have potential for malignant transformation. This study was planned to determine the incidence of atypical endometriosis and its cytological criteria, to evaluate the malignant potential of atypical endometriosis via immunohistochemical methods (p53). In this study we evaluated 140 samples obtained from 120 cases of ovarian endometriosis and 10 ovarian endometrioid carcinomas that have been previously diagnosed histopathologically. We re-evaluated endometriosis cases with respect to their epithelial and stromal features, existence of acute or chronic inflammatory cells in endometriotic epithelium or stroma and other accompanying histological findings. We observed atypia in 7 (5.8%) cases; reactive atypia in 37 (30.8%) cases, no atypia in 76 (63.4%) cases. We evaluated immunohistochemical p53 expression in 7 atypical cases, 37 reactive atypical cases, and in 10 of those without atypia and in 10 endometrioid carcinoma cases. We noted no staining in cases with atypia, reactive atypia and without atypia while 3 cases of endometrioid carcinoma had positive staining for p53. We concluded that prominent nucleolus and angulation of nuclear contour could be added to criteria of atypia that were mentioned before in the literature. In our study, even though p53 expression could not be shown with immunohistochemical methods in atypical endometriotic cases; it can not be determined that atypical endometriosis lesions are not premalignant. Still, endometriosis cases should be evaluated carefully by the pathologist for foci of cytological atypia and it should be kept in mind that malignant transformation might occur in these atypical endometriosis cases.
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Abstract

It has been reported that cases of ovarian endometriosis those with epithelial cytological atypia have potential for malignant transformation. This study was planned to determine the incidence of atypical endometriosis and its cytological criteria, to evaluate the malignant potential of atypical endometriosis via immunohistochemical methods (p53). In this study we evaluated 140 samples obtained from 120 cases of ovarian endometriosis and 10 ovarian endometrioid carcinomas that have been previously diagnosed histopathologically. We re-evaluated endometriosis cases with respect to their epithelial and stromal features, existence of acute or chronic inflammatory cells in endometriotic epithelium or stroma and other accompanying histological findings. We observed atypia in 7 (5.8%) cases; reactive atypia in 37 (30.8%) cases, no atypia in 76 (63.4%) cases. We evaluated immunohistochemical p53 expression in 7 atypical cases, 37 reactive atypical cases, and in 10 of those without atypia and in 10 endometrioid carcinoma cases. We noted no staining in cases with atypia, reactive atypia and without atypia while 3 cases of endometrioid carcinoma had positive staining for p53. We concluded that prominent nucleolus and angulation of nuclear contour could be added to criteria of atypia that were mentioned before in the literature. In our study, even though p53 expression could not be shown with immunohistochemical methods in atypical endometriotic cases; it can not be determined that atypical endometriosis lesions are not premalignant. Still, endometriosis cases should be evaluated carefully by the pathologist for foci of cytological atypia and it should be kept in mind that malignant transformation might occur in these atypical endometriosis cases. Description

Keywords

Adult; Endometriosis/genetics/metabolism/*pathology; Epithelial Cells/metabolism/*pathology; Female; Gene Expression; *Genes, p53; Humans; Immunoenzyme Techniques; *Mutation; Ovarian Diseases/genetics/metabolism/*pathology; Retrospective Studies; Tumor Suppressor Protein p53/*metabolism Fields of Science Citation WoS Q Scopus Q OpenCitations Citation Count N/A Volume 7 Issue 1

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Epithelial Cells Genes, p53 Mutation Ovarian Diseases Tumor Suppressor Protein p53 Adult Endometriosis Endometriosis Endometriosis Epithelial Cells Epithelial Cells Female Gene Expression Humans Immunoenzyme Techniques Ovarian Diseases Ovarian Diseases Ovarian Diseases Retrospective Studies

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