Ovarian carcinoma arising in atypical endometriosis.
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This report describes a case of clear-cell carcinoma arising in an ovary with endometriosis showing atypia, highlighting the need to scrutinize atypical endometriosis for potential preneoplastic lesions.
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Abstract
Malignant transformation is a rare but recognized complication of gonadal and extragonadal endometriosis. Morphologic documentation of the continuous transition from benign endometrioid epithelium through epithelial atypia to invasive carcinoma within the same organ is necessary to prove that the cancer arose from endometriosis. This stringent criterion, put forward by Scott, has rarely been fulfilled. We report a case with a chronologic association between ovarian endometriosis showing foci of atypia and a subsequent large clear-cell carcinoma arising in the same ovary 3 years later. We recommend close scrutiny of cellular atypia in endometriosis to define lesions that may be preneoplastic and require an extended surgical approach.
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Cited by (50)
- Immune pathway through endometriosis to ovarian cancer 2024
- Is ovarian cystectomy for atypical ovarian endometrioma safe?: A single center study 2022
- The Clinical Characteristics and Treatment Results in the Patients with Clear Cell Carcinoma of the Ovary 2021
- Evaluation of PTEN and Ki67 Expression in Typical and Atypical Endometriosis and Endometriosis Associated Ovarian Cancer 2020
- Atypical endometriosis is related to a higher recurrence rate 2020
- Decrease expressions of ARID1A in non-atypical, atypical endometriosis cyst and ovarian clear cell carcinoma as a biomarker of malignancy transformations 2019
- Long-Term Follow-Up after Surgical Management for Atypical Endometriosis: A Series of Nine Cases 2019
- Endometriosis-associated ovarian cancer is a single entity with distinct clinicopathological characteristics 2019
- Endometriosis and Endometriosis-Associated Tumors 2019
- Endométriose ombilicale: Présentation anatomoclinique, aspects en imagerie et attitude thérapeutique 2017
- Endometriosis-associated ovarian carcinoma site in particular structures of the abdominal cavity and the pelvis 2016
- REVIEW Possible Role of Ovarian Epithelial Inflammation in Ovarian Cancer 2016
- Lokalizacja raków jajnika związanych z endometriozą w poszczególnych strukturach jamy brzusznej i miednicy 2016
- Elevated RON protein expression in endometriosis and disease-associated ovarian cancers 2016
- Endometriosis and ovarian cancer: links, risks, and challenges faced 2015
- Precancerous Lesions of Ovarian Clear Cell and Endometrioid Carcinomas 2015
- Inducing malignant transformation of endometriosis in rats by long‐term sustaining hyperestrogenemia and type <scp>II</scp> diabetes 2014
- Novel insights on the malignant transformation of endometriosis into ovarian carcinoma 2014
- Endometriosis‐Associated Ovarian Cancer 2014
- Malignant Transformation from Endometriosis to Atypical Endometriosis and Finally to Endometrioid Adenocarcinoma within 10 Years 2013
- Endometriosis and ovarian cancer 2013
- Increased risk for ovarian cancer and borderline ovarian tumours in subfertile women with endometriosis 2013
- Les cancers de l’ovaire associés à l’endométriose : physiopathologie et conséquences sur la pratique clinique 2013
- Ovarian carcinoma associated with endometriosis 2013
- Malignant Transformation of Endometriosis Within the Urinary Bladder 2012
- Loss of ARID1A/BAF250a expression in ovarian endometriosis and clear cell carcinoma. 2012
- Pathogenesis of Ovarian Clear Cell Adenofibroma, Atypical Proliferative (Borderline) Tumor, and Carcinoma: Clinicopathologic Features of Tumors with Endometriosis or Adenofibromatous Components Support Two Related Pathways of Tumor Development 2011
- Clear cell adenocarcinoma of the ovary arising in atypical endometriosis: a report of eight cases 2011
- The relationship of endometriosis and ovarian malignancy: a review 2008
- Clinicopathological features and prognosis of Thai women with endometrioisis-associated ovarian carcinoma. 2007
- Atypical Ovarian Endometriosis 2006
- Endometriosis as a model for inflammation–hormone interactions in ovarian and breast cancers 2006
- Relationship of Benign Gynecologic Diseases to Subsequent Risk of Ovarian and Uterine Tumors 2005
- Ovarian cancer risk associated with varying causes of infertility 2004
- Endometriosis-related malignancies 2003
- Prevalence of endometriosis in malignant epithelial ovary tumours 2003
- Endometriosis-related malignancies 2003
- Endometriosis and ovarian cancer: Thoughts on shared pathophysiology 2003
- Peritoneal Lesions Related to Ovarian Neoplasms 2003
- Ovarian endometriosis 2003
- Research Aspects of Endometriosis Surgery 2002
- Management of ovarian endometriomas 2002
- Atypical epithelial changes and mutant p53 gene expression in ovarian endometriosis 2001
- Endometriosis-Associated Ovarian Carcinoma (EAOC): An Entity Distinct from Other Ovarian Carcinomas as Suggested by a Nested Case-Control Study 2001
- Ovarian Endometriosis Associated with Ovarian Carcinoma: A Clinicopathological and Immunohistochemical Study 2000
- Prevalence of Endometriosis in Ovarian Cancer 2000
- Possible Role of Ovarian Epithelial Inflammation in Ovarian Cancer 1999
- Clear cell carcinoma arising from sigmoidal subserosal endometriosis 1999
- Cervical/vaginal endometriosis with atypia: A cytohistopathologic study 1999
- A pregnant woman with clear cell adenocarcinoma of the ovary arising from endometriosis and with benign and borderline adenofibroma of the clear cell and endometrioid types 1997
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