REVIEW Possible Role of Ovarian Epithelial Inflammation in Ovarian Cancer

Roberta B. Ness, Carrie M. Cottreau
In: http://jnci.oxfordjournals.org/content/91/17/1459.full.pdf · 2016 · W2746752699
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review proposes that ovarian epithelial inflammation, potentially linked to ovulation and other risk factors like asbestos and endometriosis, is a common underlying mechanism in ovarian cancer development.

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Abstract

Ovarian cancer is a commonly fatal disease for which pre-vention strategies have been limited, in part because of a lack of understanding of the underlying biology. This paper re-views the epidemiologic literature in the English language on risk factors and protective factors for ovarian cancer and proposes a novel hypothesis that a common mechanism un-derlying this disease is inflammation. Previous hypotheses about the causes of ovarian cancer have attributed risk to an excess number of lifetime ovulations or to elevations in ste-roid hormones. Inflammation may underlie ovulatory events because an inflammatory reaction is induced during the pro-cess of ovulation. Additional risk factors for ovarian cancer, including asbestos and talc exposure, endometriosis (i.e., ec-topic implantation of uterine lining tissue), and pelvic in-flammatory disease, cannot be directly linked to ovulation or

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endometriosis

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