Cervical/vaginal endometriosis with atypia: A cytohistopathologic study

Mulvany NJ, Nicholas J. Mulvany, N J Mulvany, Surtees V, Valerie Surtees, V Surtees
Diagnostic cytopathology · 1999 · vol. 21(3) , pp. 188–193 · doi:10.1002/(sici)1097-0339(199909)21:3<188::aid-dc8>3.0.co;2-d · PMID:10450104 · W2055606728
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Preoperative smears from 10 women with cervical or vaginal endometriosis showed atypical cells, but biopsies revealed epithelial atypia in endometriosis without cancer, offering features to distinguish it from adenocarcinoma.

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Abstract

Neoplastic or atypical glandular epithelial cells of uncertain significance were reported in the preoperative smears from 10 women with cervical or vaginal endometriosis. Subsequent conization and vaginal biopsy revealed endometriotic tissue with variable epithelial atypia, but no evidence of in situ or invasive carcinoma. Review of the smears revealed appearances similar to those seen in "high cervical sampling" or in smears from patients with tubal metaplasia. The presence of large cohesive cell sheets with retained cell polarity and well-defined cytoplasmic edges, of endometrial cell "whorls" and tubular structures, and of endometrial-like stromal cells coupled with the absence of three-dimensional cell clusters, peripheral cell-sheet crowding, "cell feathering," and pseudostratified cell strips are features helpful in the distinction between cervical/vaginal endometriosis and adenocarcinoma. Diagn. Cytopathol. 1999;21:188-193.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Uterine Cervical Diseases Vaginal Diseases Adult Biopsy Conization Endometriosis Epithelial Cells Epithelial Cells Female Humans Middle Aged Uterine Cervical Diseases Vaginal Diseases Vaginal Smears

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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