Clinical and Pathological Significance of Cellular Atypia in Endometriosis

Ioana Maria Maier, Adrian Cornel Maier, Andrada Crișan, Lucian Puşcaşiu, Lucian Pușcașiu
Medicina (Kaunas, Lithuania) · 2021 · vol. 57(5) , pp. 453 · doi:10.3390/medicina57050453 · PMID:34066945 · PMC8148576 · W3163903549
article OA: gold CC0 ⤵ 2 in-corpus citations
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This study found that atypical endometriosis is more common in the left ovary and is significantly correlated with recurrence, particularly in patients under 40 and with cysts larger than 7 cm.

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Abstract

Objective: To highlight the most frequent localization of ovarian endometriosis, the presence of atypical endometriosis, and recurrences. Retrospective review of 259 patients diagnosed with ovarian endometriosis treated at Tîrgu-Mures Emergency County Hospital, Obstetric Gynecology Clinic, between January 2014 and December 2018. Methods: Data were collected and analyzed for demographics, size of ovarian endometriotic cyst, and recurrences. Results: Out of 259 patients, 51 patients presented atypia, 20 on the right, 24 on the left, and seven patients were diagnosed with endometriosis with bilateral atypia. Higher susceptibility for left localization was noted. Thirty-nine patients (15.1%) presented recurrence. A statistically significant correlation (p = 0.006) was noted between patients with recurrence and atypia compared with those without atypia and endometriotic cysts larger than 7 cm. Patients with relapse under the age of 40 were noted to have mainly atypia with localization on the right (p = 0.025, OD = 4.107). Conclusions: The presence of endometrioma was not statistically significant correlated with left or right sided localization; recurrent endometriomas larger than 7 cm represents a risk for atypical endometriosis development. Recurrence and atypia appear more often in patients under the age of 40 and are right-sided. The total removal of the endometriomas can prevent the recurrence and subsequently the appearance of atypia and secondary neoplastic conditions.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Endometriosis Endometriosis Female Humans Neoplasm Recurrence, Local Pregnancy Retrospective Studies

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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