Which factors are associated with the recurrence of endometrioma after cystectomy?
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Greater cyst dimension, higher CA-125 levels, and preoperative symptoms of non-cyclic pelvic pain and dysmenorrhoea may be associated with endometrioma recurrence after cystectomy.
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Abstract
Endometrioma is the most common form of endometriosis and is a sign of wide-spread disease in symptomatic patients. Medical treatment options can be successful in endometrioma smaller than 1 cm, but ineffective for growing and symptomatic endometriomas. Conservative surgical interventions that preserve fertility, such as laparoscopic removal or destruction of endometriotic tissue or aspiration of cystic content are typically used to treat the condition. One of the most frustrating aspects of endometrioma treatment is disease recurrence. The underlying mechanisms explaining recurrence are uncertain. Several risk factors have been evaluated in order to predict recurrence after cystectomy. In looking at the results overall, our study can conclude that the presence of greater cyst dimension, higher CA-125 level, presence of preoperative symptoms of non-cyclic pelvic pain, dysmenorrhoea and adhesion extension may be associated with recurrent endometrioma. In clinical practice, identification of risk factors for recurrence helps clinicians to inform patients. Impact statement What is already known on this subject: Endometrioma is the most common form of endometriosis and is a sign of wide-spread disease in symptomatic patients. One of the most frustrating aspects of endometrioma treatment is disease recurrence. Several risk factors have been evaluated in order to predict recurrence after cystectomy. However, the risk factors have not been precisely defined. What the results of this study add: This study aimed to investigate the contribution of possible risk factors to the recurrence of endometrioma after laparoscopic surgery. In looking at the results overall, our study can conclude that the presence of greater cyst dimension, higher CA-125 level, adhesion extension, presence of preoperative symptoms of non-cyclic pelvic pain and dysmenorrhoea may be associated with recurrent endometrioma. What the implications of these findings are for clinical practice and/or further research: In clinical practice, identification of risk factors for recurrence helps clinicians to inform patients. Detection of preoperative risk factors would be helpful in counselling patients on their future prognosis. This may also increase treatment success by providing accurate preoperative treatment planning and by assisting the scheduling of postoperative follow-ups.
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Cited by (18)
- Rethinking endometriosis recurrence: from clinical challenge to biological opportunity 2026
- Ovarian endometrioma recurrence after laparoscopic surgery: First assessment of ACSAP predicting score 2024
- Pathophysiology and Clinical Implications of Ovarian Endometriomas 2024
- The Value of CA125 and CA19-9 in the Diagnosis of Stage Ⅲ and Ⅳ Endometriosis 2024
- Factors that Increase the Likelihood of Ovarian Endometriosis Relapsing after Surgical Excision: A Systematic Review and Meta-Analysis 2023
- Risk factors for recurrent endometriosis after conservative surgery in a quaternary care center in southern Thailand 2023
- Status and related factors of postoperative recurrence of ovarian endometriosis: a cross-sectional study of 874 cases 2023
- Recurrent ovarian endometrioma after conservative surgery 2022
- Research progress of CA125 in endometriosis: Teaching an old dog new tricks 2022
- Recurrence Rate and Risk Factors for the Recurrence of Ovarian Endometriosis after Laparoscopic Ovarian Cystectomy 2021
- Ovarian reserve and recurrence 1 year post-operatively after using haemostatic sealant and bipolar diathermy for haemostasis during laparoscopic ovarian cystectomy 2021
- Risk factors for ovarian endometrioma recurrence following surgical excision: a systematic review and meta‑analysis 2021
- Clinical and Pathological Significance of Cellular Atypia in Endometriosis 2021
- OVARIAN ENDOMETRIOSIS: THE MODERN POSSIBILITIES OF RELAPSE PREDICTION 2020
- Long-term hormonal treatment reduces repetitive surgery for endometriosis recurrence 2020
- Atypical endometriosis is related to a higher recurrence rate 2020
- Recurrent endometriosis: a battle against an unknown enemy 2019
- Risk factors for postoperative recurrence of ovarian endometriosis: long-term follow-up of 358 women 2019
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- europepmc
- last seen: 2026-06-21T06:12:49.409960+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:20:13.663096+00:00
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