Risk factors for ovarian endometrioma recurrence following surgical excision: a systematic review and meta‑analysis
This meta-analysis found age at surgery, CA125 level, cyst size, dysmenorrhea, endometriosis surgery history, pre-operative medication, and rASRM score to be risk factors for endometrioma recurrence, while post-operative pregnancy was protective.
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This systematic review and meta-analysis evaluated studies published before October 2020 to identify risk factors for ovarian endometrioma (OMA) recurrence after surgical excision, searching PubMed, Embase, the Cochrane Library, CNKI, and Wanfang and pooling odds ratios or standard mean differences. Across included evidence, recurrence was associated with younger/older age at surgery (SMD −0.28), higher CA125 level (SMD 0.51), larger cyst size (SMD 0.35), dysmenorrhea (OR 1.47), history of endometriosis-related surgery (OR 2.60), pre-operative medication (OR 2.13), and higher rASRM score (SMD 0.33), while post-operative pregnancy showed a protective association (OR 0.22). A key limitation noted in the paper is that the effects of bilateral involvement, coexisting adenomyosis, and post-operative medication on recurrence require further investigation. This paper is centrally about endometriosis — it specifically meta-analyzes predictors of ovarian endometrioma recurrence after excision, directly relevant to endometriosis outcomes.
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Cited by (19)
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- Rethinking endometriosis recurrence: from clinical challenge to biological opportunity 2026
- Endometrioma and Infertility 2025
- Risk of endometriosis progression in infertile women trying to conceive naturally or using IVF 2025
- Machine-learning-derived prediction models of recurrence of ovarian endometriosis after laparoscopic surgery 2025
- Plasma energy ablation versus cystectomy in fertility-sparing surgery for endometriomas: impact on recurrence and ovarian reserve 2025
- Long-term therapy with dienogest or other oral cyclic estrogen-progestogen can reduce the need for ovarian endometrioma surgery 2024
- The dilemma of management of patients with endometrioma and infertility 2024
- Endometrioid ovarian cysts: risk factors for recurrence 2024
- Ovarian endometrioma recurrence after laparoscopic surgery: First assessment of ACSAP predicting score 2024
- Status and related factors of postoperative recurrence of ovarian endometriosis: a cross-sectional study of 874 cases 2023
- Women operated for recurrent endometrioma exhibit more multiple deep infiltrating endometriosis lesions 2023
- Conservative treatment strategies for endometrioid ovarian cysts: A review 2023
- Treatment after endometrioma recurrence: a narrative review 2023
- Factors that Increase the Likelihood of Ovarian Endometriosis Relapsing after Surgical Excision: A Systematic Review and Meta-Analysis 2023
- Recurrent ovarian endometrioma after conservative surgery 2022
- PECULIARITIES OF CLINICAL AND PARACLINICAL INVESTIGATIONS OF WOMEN WITH OVARIAN ENDOMETRIOMAS IN COMBINATION WITH PELVIC INFLAMMATORY DISEASE 2022
- Effect of the mode of delivery on the risk of endometriosis recurrence: a retrospective cohort study 2022
- Research progress of CA125 in endometriosis: Teaching an old dog new tricks 2022
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