Endometriosis‐Associated Ovarian Cancer

Leslie A. Garrett, Marcela G. del Carmen
In: Uncommon Gynecologic Cancers · 2014 · pp. 94–108 · doi:10.1002/9781118655344.ch8 · W1499039708
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review examines the association between endometriosis and ovarian cancer, concluding that treatment strategies for endometriosis-associated ovarian cancer are identical to those for non-endometriosis-associated ovarian cancer.

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Abstract

Most studies describing the relationship between endometriosis and ovarian cancer reference Sampson's original histopathologic criteria to classify cancers arising in endometriosis. This chapter reviews the literature on the association between endometriosis and ovarian cancer and outlines a treatment paradigm for endometriosis-associated ovarian cancer (EAOC). The treatment strategies for patients with EAOC are the same as for those with non- endometriosis-associated EOC. For both endometrioid and clear cell EAOC, the mainstay of treatment remains surgical staging/debulking and systemic therapy with platinum- and taxane-based chemotherapy. Two mechanisms have been proposed to explain the association between endometriosis and ovarian cancer. The first model proposes that endometriosis cells undergo transformation to cancer. In the second model, endometriosis coexists with ovarian cancer and the association may be the result of shared risk factors/antecedent mechanisms such as genetic predisposition, immune dysregulation, and environmental factors.

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endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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last seen: 2026-06-04T00:00:01.174412+00:00
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