The proline form of p53 codon 72 polymorphism is associated with endometriosis

Chi Chen Chang, Chang CC, Chi-Chen Chang, Yao‐Yuan Hsieh, Hsieh YY, Yao Yuan Hsieh, Tsai FJ, Fuu Jen Tsai, Fuu‐Jen Tsai, Chang‐Hai Tsai, Chang Hai Tsai, Tsai CH, Horng Der Tsai, Tsai HD, Horng-Der Tsai, Cheng Chieh Lin, Cheng‐Chieh Lin
Fertility and Sterility · 2002 · vol. 77(1) , pp. 43–45 · doi:10.1016/s0015-0282(01)02938-7 · PMID:11779589 · W2154700137
article OA: closed CC0 ⤵ 45 in-corpus citations
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This study investigated the association between the proline form of p53 codon 72 polymorphism and endometriosis, finding a significant link between the two.

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Abstract

ObjectiveTo evaluate the association between endometriosis and the p53 polymorphism.DesignProspective study.SettingDepartment of gynecology and genetics in a medical center.Patient(s)Women with and without endometriosis.Intervention(s)Women were categorized as having moderate or severe endometriosis (n = 118) or no endometriosis (n = 140).Main outcome measure(s)Polymerase chain reaction was used to detect p53 codon 72 polymorphisms (arginine homozygosity, heterozygosity, and proline homozygosity). Associations between endometriosis and p53 polymorphisms were evaluated.Result(s)The distributions of different p53 polymorphisms differed significantly between groups. The respective proportions of arginine homozygotes, heterozygotes, and proline homozygotes were 10.2%, 66.9%, and 22.9% in the group with endometriosis and 30.7%, 50%, and 19.3% in the group without endometriosis.Conclusion(s)Endometriosis is associated with p53 polymorphism. p53 arginine homozygotes have lower risk for endometriosis. Heterozygotes and proline homozygotes have higher risk for endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Codon Endometriosis Genes, p53 Polymorphism, Genetic Proline Tumor Suppressor Protein p53 Amino Acid Substitution Asian People Codon Endometriosis Endometriosis Female Genotype Humans Polymerase Chain Reaction Reference Values Taiwan Tumor Suppressor Protein p53

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (34)

Cited by (45)

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