A Meta-analysis of the Association between p53 Codon 72 Polymorphism and Susceptibility to Endometriosis

Gwan Gyu Song, Young Ho Lee
Immunological investigations · 2014 · vol. 43(6) , pp. 595–605 · doi:10.3109/08820139.2013.833623 · PMID:24999736 · W1963701641
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This meta-analysis of nine studies found no overall association between the p53 codon 72 polymorphism and endometriosis, but identified a significant association in East Asians.

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Abstract

OBJECTIVE: The aim of this study was to determine whether the p53 codon 72 polymorphism is associated with susceptibility to endometriosis. METHODS: A meta-analysis was conducted on the associations between the p53 codon 72 polymorphism and endometriosis using 1) allele contrast, 2) a recessive model, 3) a dominant model, and 4) homozygote contrast. RESULTS: Nine studies involving 1,803 patients and 2,006 controls were considered in the meta-analysis. Meta-analysis of the p53 polymorphism showed no association between endometriosis and the p53 C allele (odds ratio (OR) = 1.087, 95% confidence interval (CI) = 0.921-1.282, p = 0.323). Stratification by ethnicity indicated no association between the p53 C allele and endometriosis in Europeans and Latin Americans. However, a significant association was found between the p53 C allele and endometriosis in East Asians (OR = 1.405, 95% CI = 1.065-1.854, p = 0.016). Furthermore, association was found between the p53 polymorphism and endometriosis in East Asians using the dominant model (OR = 2.046, 95% CI = 1.123-3.730, p = 0.019). CONCLUSIONS: This meta-analysis demonstrates that the p53 codon 72 polymorphism may be associated with susceptibility to endometriosis in East Asians, but not in Europeans and Latin Americans.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Ethnicity Tumor Suppressor Protein p53 Alleles Codon Codon Endometriosis Female Genetic Association Studies Genetic Predisposition to Disease Humans Polymorphism, Genetic Tumor Suppressor Protein p53

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References (31)

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