The association of PTPN22 polymorphism with endometriosis: effect of genetic and clinical factors

F Gloria-Bottini, Gloria-Bottini F, F. Gloria‐Bottini, Maria Ammendola, Ammendola M, M Ammendola, Saccucci P, P. Saccucci, Adalgisa Pietropolli, A Pietropolli, A Magrini, Andrea Magrini, Magrini A, Bottini E, E. Bottini
European journal of obstetrics, gynecology, and reproductive biology · 2013 · vol. 169(1) , pp. 60–63 · doi:10.1016/j.ejogrb.2013.01.014 · PMID:23453606 · W2074533136
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This study found that the PTPN22 *T allele is associated with endometriosis in women with the ACP1*C allele, p53 codon 72 *Pro allele, or prolonged pharmacological treatment.

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Abstract

ObjectiveTo investigate the possible effect of clinical and genetic variables on the association between PTPN22 and endometriosis.MethodsPTPN22, ACP₁ and p53 codon 72 genetic polymorphisms and duration of previous pharmacological treatment were studied. The study sample consisted of 132 women hospitalized for endometriosis diagnosed by laparoscopic intervention and histologically confirmed: 359 healthy blood donors were studied as controls. PTPN22, ACP1 and p53 codon 72 genotypes were determined by DNA analysis. Discriminant statistical analysis, logistic regression analysis, chi square of independence, power test and linear correlation were performed using SPSS programs.ResultsA significant increase of PTPN22 *T allele in endometriosis is observed in women carrying ACP1*C allele, in women carrying p53 codon 72 *Pro allele and in women with prolonged pharmacological treatment.ConclusionsPTPN22 may not be a primary factor in the etiology of endometriosis but may cooperate with clinical and genetic factors influencing susceptibility and clinical course of disease. These new observations point to a multifactorial origin of endometriosis and help to explain the reported differences between human populations concerning the association between PTPN22 and endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Protein Tyrosine Phosphatase, Non-Receptor Type 22 Protein Tyrosine Phosphatases Proto-Oncogene Proteins Tumor Suppressor Protein p53 Adult Alleles Endometriosis Female Humans Polymorphism, Genetic Protein Tyrosine Phosphatase, Non-Receptor Type 22 Protein Tyrosine Phosphatases Proto-Oncogene Proteins Tumor Suppressor Protein p53

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