Acid phosphatase locus 1 genetic polymorphism, endometriosis, and allergy

Maria Ammendola, Ammendola M, Adalgisa Pietropolli, Saccucci P, Patrizia Saccucci, P. Saccucci, Emilio Piccione, E. Bottini, Bottini E, Egidio Bottini, Fulvia Gloria-Bottini, Gloria-Bottini F, F. Gloria‐Bottini
Fertility and sterility · 2008 · vol. 90(4) , pp. 1203–1205 · doi:10.1016/j.fertnstert.2007.10.014 · PMID:18490013 · W2059202673
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This study investigated the association between the Acid phosphatase locus 1 (ACP1) genetic polymorphism and endometriosis, as well as allergy.

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Abstract

Recent studies suggest that acid phosphatase locus 1 (ACP1) could be involved in T-cell antigen receptor signaling and in immune disorders. The present study shows that the ACP1( *)C allele, which is associated with elevated enzymatic activity, is significantly more common in women with endometriosis than in healthy women, but is less common in allergic than in nonallergic subjects. These findings suggest that carriers of high activity ACP1 genotypes are more susceptible to endometriosis but less susceptible to allergic manifestations than carriers of other ACP1 genotypes.

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Condition tags

endometriosis

MeSH descriptors

Acid Phosphatase Endometriosis Endometriosis Hypersensitivity Hypersensitivity Polymorphism, Single Nucleotide Risk Assessment Acid Phosphatase Adult Causality Comorbidity Endometriosis Endometriosis Female Genetic Predisposition to Disease Genetic Predisposition to Disease Genetic Predisposition to Disease Heterozygote Humans Hypersensitivity

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