Association of p53 and CDKN1A genotypes with endometriosis

Tsung-Ho Ying, Ying TH, Tseng CJ, Chih-Jen Tseng, Tsai SJ, Su‐Ju Tsai, Su-Ju Tsai, Shu-Ching Hsieh, Hsieh SC, Hong-Zin Lee, Lee HZ, Yi-Hsien Hsieh, Yi‐Hsien Hsieh, Hsieh YH, DA-Tian Bau, Da‐Tian Bau, Bau DT
Anticancer research · 2011 · vol. 31(12) , pp. 4301–6 · PMID:22199295 · W1923832916
Observational OA: closed CC0 ⤵ 15 in-corpus citations
View on OpenAlex View on PubMed
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-10 ⓘ

This study investigated p53 and CDKN1A polymorphisms in a Taiwanese population, finding that the p53 codon 72 C (Pro) allele is associated with an increased risk of endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

BACKGROUND: The tumor suppressor p53 protein plays a critical role in different cellular processes in response to DNA damage and it is responsible for transcriptional induction of the p21 (CDKN1A/WAF1/CIP1) gene. Both p53 and p21 are thought to play major roles in the development of human malignancy. Polymorphic variants of p53 at codon 72, and CDKN1A at codon 31, have been found to be associated with cancer susceptibility, but few studies have investigated their effect on endometriosis risk. MATERIALS AND METHODS: In this hospital-based case-control study, we investigated the association of p53 codon 72 and CDKN1A codon 31 polymorphisms with endometriosis susceptibility in a Taiwanese population. In total, 180 patients with endometriosis, and 330 age-matched controls in Central Taiwan were recruited and genotyped. RESULTS: We found a significant difference in the distribution of the p53 genotype, but not the CDKN1A genotype, between the endometriosis and control groups. Individuals with the C (Pro) allele at p53 codon 72 had a 1.6-fold increased odds ratio of endometriosis, and those with Arg/Pro and Pro/Pro genotypes for p53 codon 72 had a 1.84- and 2.74-fold (95% confidence interval=1.17-2.92 and 1.58-4.74) increased risk of endometriosis compared to those with Arg/Arg, respectively. The distribution of haplotype combinations of p53 codon 72 and CDKN1A codon 31 was statistically different in the endometriosis and control groups. The percentages of the three subgroups with p53 CC homozygote were all higher in the endometriosis group than in the control group. CONCLUSION: Our findings suggest that the C (Pro) allele of p53 codon 72 may be associated with the development of endometriosis, and could serve as a potential biomarker for early prediction of this disease.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Biomarkers Cyclin-Dependent Kinase Inhibitor p21 Endometriosis Genes, p53 Genes, p53 Adult Adult Alleles Alleles Biomarkers Biomarkers Case-Control Studies Case-Control Studies Cell Proliferation Cell Proliferation Codon Codon Cyclin-Dependent Kinase Inhibitor p21 Cyclin-Dependent Kinase Inhibitor p21 Endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (51)

Cited by (15)

Source provenance

europepmc
last seen: 2026-10-19T06:17:24.038039+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-10-08T21:09:44.076416+00:00
License: CC0 · commercial use OK