Polymorphism of the progesterone receptor gene associated with endometriosis in patients from Goiás, Brazil

I R Costa, Iasmim Ribeiro da Costa, R C P C Silva, A B Frare, Ariane Bocaletto Frare, C T X Silva, B M Bordin, S R Souza, C L Ribeiro Júnior, K K V O Moura
Genetics and molecular research : GMR · 2011 · vol. 10(3) , pp. 1364–1370 · doi:10.4238/vol10-3gmr913 · PMID:21751163 · W2325193681
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This study found a significantly higher frequency of PROGINS gene polymorphisms (A1/A2 and A2/A2) in Brazilian women diagnosed with endometriosis compared to controls.

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Abstract

We investigated a possible link between endometriosis and polymorphism of the progesterone receptor gene (PROGINS). The endometriosis group consisted of 54 patients with a diagnosis of endometriosis by laparoscopy, and the control group comprised 44 women without endometriosis. Genotypes for PROGINS polymorphisms (A1/A1, A1/A2 and A2/A2) were determined by polymerase chain reaction and analyzed on a 2% agarose gel stained with ethidium bromide. The frequency of polymorphic genotypes (A1/A2 and A2/A2) was significantly higher in patients with endometriosis (33%) than in the control group (16%). We conclude that there is a significant correlation between PROGINS polymorphism and endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Receptors, Progesterone Adult Alu Elements Alu Elements Brazil Endometriosis Female Genetic Predisposition to Disease Genome-Wide Association Study Genotype Humans Middle Aged Polymorphism, Genetic Receptors, Progesterone Receptors, Progesterone Risk Factors

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References (21)

Cited by (11)

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