Polymorphism of the progesterone receptor gene associated with endometriosis in patients from Goiás, Brazil

Costa IR, Iasmim Ribeiro da Costa, I R Costa, Silva RC, R C P C Silva, A B Frare, Ariane Bocaletto Frare, Frare AB, C T X Silva, Silva CT, Bordin BM, B M Bordin, S R Souza, Souza SR, C L Ribeiro Júnior, Ribeiro Júnior CL, Moura KK, K K V O Moura
Genetics and molecular research : GMR · 2011 · vol. 10(3) , pp. 1364–1370 · doi:10.4238/vol10-3gmr913 · PMID:21751163 · W2325193681
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This study found a significantly higher frequency of PROGINS gene polymorphisms (A1/A2 and A2/A2) in Brazilian women diagnosed with endometriosis compared to controls.

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Abstract

We investigated a possible link between endometriosis and polymorphism of the progesterone receptor gene (PROGINS). The endometriosis group consisted of 54 patients with a diagnosis of endometriosis by laparoscopy, and the control group comprised 44 women without endometriosis. Genotypes for PROGINS polymorphisms (A1/A1, A1/A2 and A2/A2) were determined by polymerase chain reaction and analyzed on a 2% agarose gel stained with ethidium bromide. The frequency of polymorphic genotypes (A1/A2 and A2/A2) was significantly higher in patients with endometriosis (33%) than in the control group (16%). We conclude that there is a significant correlation between PROGINS polymorphism and endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Receptors, Progesterone Adult Adult Alu Elements Alu Elements Alu Elements Brazil Brazil Endometriosis Endometriosis Female Female Genetic Predisposition to Disease Genetic Predisposition to Disease Genome-Wide Association Study Genome-Wide Association Study Genotype Genotype Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (21)

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