Association of genetic polymorphisms of estrogen and progesterone receptors and endometriosis: Meta-analysis

Priscila Prais Carneiro, Bruna Vicente de Oliveira, Antônio Márcio Teodoro Cordeiro Silva
In: Journal of Endometriosis and Pelvic Pain Disorders · 2019 · vol. 11(1) , pp. 25–36 · doi:10.1177/2284026518819516 · W2912501764
article OA: closed CC0 ⤵ 2 in-corpus citations
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This meta-analysis of 20 studies found no association between polymorphisms in estrogen receptor alpha, estrogen receptor beta, and progesterone receptor genes and susceptibility to endometriosis.

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Abstract

Purpose: To investigate the association between polymorphisms in the genes of estrogen receptor alpha, estrogen receptor beta, and progesterone receptor and the genesis of endometriosis. Methods: Systematic review and meta-analysis of articles published fully in the PubMed database, in Portuguese, English, or Spanish, from 2006 to 2017, using the descriptors: “endometriosis,” “polymorphism,” “ESR1,” “ESR2,” “PROGINS,” “rs9340799,” “rs4986938,” and “rs1042838.” Results: A total of 20 studies were included based on the criterion of search for susceptibility to endometriosis related to polymorphisms of estrogen receptor alpha, estrogen receptor beta, and progesterone receptor genes. Analysis of all polymorphisms found no association with endometriosis. Conclusion: This meta-analysis showed that estrogen receptor alpha, estrogen receptor beta, and progesterone receptor polymorphisms are not related to susceptibility to endometriosis. However, such results may be able to provide more detailed interpretations of how they influence the pathogenesis of endometriosis.

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endometriosis

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