P450 arom y microambiente estrogénico en endometrios eutópicos de mujeres con endometriosis

M Cecilia Johnson P, M Cecilia Johnson, Claudio Pinto, Claudio Pinto O, Alessandra Alves, Alessandra Alves L, Alberto Palomino, Alberto Palomino A, Ariel Fuentes G, Ariel Fuentes, M Angélica Boric, Meo S, Margarita Vega, Margarita Vega B
Revista medica de Chile · 2004 · vol. 132(12) , pp. 1475–82 · doi:10.4067/s0034-98872004001200004 · PMID:15743158 · W2107969710
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Abstract

BACKGROUND: Endometriosis, a common gynecologic disorder characterized by endometrial glands and stroma outside the uterus, is diagnosed by direct visualization of peritoneal and ovarian implants during laparoscopy. AIM: To study the estrogenic microenvironment in eutopic endometria of women with and without endometriosis. PATIENTS AND METHODS: Eutopic endometria, obtained during laparoscopy from 23 women with endometriosis and 20 fertile cyclic women undergoing tubal sterilization, was studied. P450Arom mRNA expression (RT-PCR) was measured. Also, P450Arom activity was assessed measuring testosterone conversion to estradiol and the concentration of this last hormone in cultured endometrial explants. RESULTS: Age and body mass index was similar in both groups studied. Seventy nine percent of endometria from women with endometriosis and in 29.4% from control group expressed P450Arom mRNA (p <0.01). The intensity of the band was higher in secretory endometria from women with endometriosis when compared to controls (p <0.01), but it was similar during the proliferative phase. Estradiol secretion to the culture media by proliferative endometria explants from women with endometriosis was 3-fold higher than secretory endometria (p <0.01) and endometria from control women in both phases. P450Arom activity, in the presence of testosterone, was 7-fold higher in endometrial cultures from women with endometriosis, when compare with the basal culture (p <0.01). However, in endometrial explant cultures from control women, this activity was not statistical different. CONCLUSIONS: These results indicate that in women with endometriosis, the microenvironment in the endometria is estrogenic as a consequence of an increased expression and activity of the P450Arom.

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mesh:D004715endometriosis

MeSH descriptors

Aromatase Endometriosis Endometrium Estrogens Aromatase Biopsy Case-Control Studies Cells, Cultured Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Estradiol Estradiol Estrogens Female Fertility Fertility

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