Effect of the immunomodulator leflunomide on the induction of endometriosis in an experimental rat model

Aytan H, Hakan Aytan, P. Caglar, Caglar P, Pinar Caglar, Dilek Şahın, Dilek Uygur, Zergeroglu S, Sema Zergeroglu, Sema Zergeroğlu, Sertac Batioglu, Sertaç Batıoğlu, Batioglu S
Fertility and sterility · 2006 · vol. 87(3) , pp. 698–701 · doi:10.1016/j.fertnstert.2006.07.1527 · PMID:17118364 · W2115875920
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⚙ AI-generated summary by claude@2026-07, 2026-07-09 ⓘ

Leflunomide treatment negatively affected the development and maintenance of surgically induced endometriosis lesions in a rat model.

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Abstract

The effect of immunomodulator leflunomide on the development of an experimental endometriosis model was assessed by surgically transplanting autologous fragments of endometrial tissue onto the inner surface of the abdominal wall and arterial cascades of the small intestines. Leflunomide was found to affect the development of endometriosis negatively and seemed to interfere with the growth and maintenance of the uterine explant in this experimental rat model.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Immunologic Factors Isoxazoles Animals Disease Models, Animal Endometriosis Endometriosis Female Immunologic Factors Isoxazoles Leflunomide Rats Uterus Uterus

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References (26)

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