The effect of estradiol on the production and secretion of complement component 3 by the rat uterus and surgically induced endometriotic tissue

K B Isaacson, Keith Isaacson, Isaacson KB, Xu Q, Qin Xu, Q Xu, C. Richard Lyttle, C R Lyttle, Lyttle CR
Fertility and sterility · 1991 · vol. 55(2) , pp. 395–402 · doi:10.1016/s0015-0282(16)54135-1 · PMID:1991537 · W2411901353
article OA: closed CC0 ⤵ 26 in-corpus citations
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This study investigated how estradiol influences the production and release of complement component 3 in both the rat uterus and experimentally created endometriotic tissue.

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Abstract

We have recently demonstrated that glandular epithelial cells isolated from human endometriotic tissue synthesize and secrete complement component 3 (C3). Furthermore, because C3 is capable of producing many of the immunological activities known to be associated with human endometriosis, we studied the production, secretion, and regulation of C3 using the rat model for endometriosis. Endometriosis was surgically induced in 20 adult female rats. The animals were then ovariectomized and one half were treated with estradiol (E2) for 3 days. Uterine luminal epithelial cells synthesized and secreted C3 only after E2 administration, whereas the uteri from control animals did not produce C3. In contrast, the ectopic endometrium from control animals produced and secreted C3, and this expression was strongly upregulated by in vivo E2 administration. We conclude that surgically induced endometriosis in the rat has properties biochemically independent from the intact uterus and may serve as a useful model to further investigate the regulation of C3 synthesis from human endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Complement C3 Endometriosis Estradiol Uterus Animals Complement C3 Complement C3 Disease Models, Animal Endometriosis Estradiol Female Immunoenzyme Techniques Rats Rats, Inbred Strains RNA, Messenger RNA, Messenger RNA, Messenger Uterus Uterus Uterus

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (28)

Cited by (26)

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