Human endometriotic xenografts in immunodeficient RAG-2/γ(c)KO mice

Greenberg LH, Laura H Greenberg, Ov D. Slayden, Slayden OD
American journal of obstetrics and gynecology · 2004 · vol. 190(6) , pp. 1788–1795 · doi:10.1016/j.ajog.2004.02.047 · PMID:15284801 · W2161711157
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Human endometriotic biopsy specimens with glands were successfully grafted into RAG-2/gamma(c)KO mice, exhibiting hormonal responsiveness and cyclic bleeding, unlike samples lacking glands.

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Abstract

ObjectiveThe purpose of this study was to create a novel animal model for studies of endometriosis.Study designTo facilitate the study of the transplantation of endometriosis into immunodeficient RAG-2/gamma(c)KO mice, endometriosis biopsy specimens were collected from 19 women by laparoscopic surgery and grafted subcutaneously into the mice, which were treated subsequently with estradiol and progesterone to create 28-day artificial cycles. The grafts were collected during the first, second, and fourth cycles and were evaluated histologically for evidence of bleeding and immunocytochemically for estrogen receptor and progesterone receptor.ResultsBiopsy specimens that contained endometrium-like glands were well accepted (>90% success). These grafts maintained glandular morphologic condition, estrogen receptor, and progesterone receptor; bled after progesterone withdrawal; and formed chocolate cysts. However, biopsy specimens that lacked glands or that consisted of peritoneal adhesions and stroma were accepted poorly <5% success) and failed to show evidence of estrogen receptor, progesterone receptor, or cyclic bleeding.ConclusionHuman endometriosis transplanted into RAG-2/gamma(c)KO mice can provide a model for endometriotic bleeding.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Immunocompromised Host Menstrual Cycle Animals Biopsy, Needle Disease Models, Animal Endometriosis Female Humans Immunohistochemistry Menstrual Cycle Mice Mice, Nude Photomicrography Receptors, Estrogen Receptors, Progesterone Receptors, Progesterone Species Specificity Tissue Transplantation Transplantation, Heterologous

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