A novel model for endometriosis

Hirotaka Masuda, Tetsuo Maruyama, Yasunori Yoshimura, Yumi Matsuzaki, Hideyuki Okano
In: Inflammation and Regeneration · 2010 · vol. 30(2) , pp. 96–102 · doi:10.2492/inflammregen.30.96 · W2056246257
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study developed a novel mouse model using human endometrial cells to reconstruct functional ectopic endometria and study endometriosis noninvasively via bioluminescence imaging.

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This 2010 review describes a novel experimental model for endometriosis using singly dispersed human endometrial cells transplanted beneath the kidney capsule of NOD/SCID/γcnull immunodeficient mice. The authors report that the grafts can reconstruct functional ectopic endometrium and reproduce hormone-dependent cyclic changes—such as proliferation, differentiation, tissue breakdown, and shedding—supported by human–mouse chimeric vessels, and that an engineered variant luciferase enables noninvasive, quantitative bioluminescence imaging of endometrial behavior in vivo. A major caveat noted is that the paper frames etiologic and pathophysiologic mechanisms as still uncertain, despite the model’s utility for studying lesion establishment. This paper is centrally about endometriosis — it outlines an in vivo human endometrial cell–based mouse model plus noninvasive imaging to study endometriotic lesion pathophysiology.

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Abstract

Human uterine endometrium has unique properties to regenerate and remodel cyclically throughout the woman's reproductive life and also gives rise to endometriosis through ectopic implantation of retrograde shedding including endometrial cells during menstruation. Endometriosis is a common and significant gynecological disorder which can lead to infertility or a certain type of ovarian cancer. However, the etiology and pathogenesis still remain uncertain. Previously, we have reported that singly dispersed cells isolated directly from human endometrium can reconstruct the functional ectopic endometria when transplanted beneath the kidney capsule of the NOD/SCID/γcnull immunodeficient mouse. In addition to the endometrium-like structure, hormone-dependent changes (e.g. proliferation, differentiation, tissue breakdown and shedding) characteristic of cycling human endometrium can be reproduced in the endometrial reconstruct whose blood is supplied by human-mouse chimeric vessels. These results indicate that singly dispersed endometrial cells have potential applications for tissue reconstitution, angiogenesis, and human-mouse chimeric vessel formation, providing implications for model mechanisms underlying the establishment of endometriotic lesions and the physiological endometrial regeneration during the menstrual cycle. Furthermore, the hormone-dependent behavior of the endometrium reconstructed from lentivirally-engineered endometrial cells expressing a variant luciferase can be assessed noninvasively and quantitatively by in vivo bioluminescence imaging. Our animal model will provide a powerful tool to investigate the pathophysiology of endometriosis and also to validate the effect of novel therapeutic agents and gene targeting on endometriosis with the noninvasive and real-time evaluation system. This animal system can be applied as a unique model for other various types of neoplastic diseases when the relevant cells are transplanted under the kidney capsule. This article describes our novel mouse model and in vivo imaging system with overviews of experimental models for endometriosis.
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Review Article A novel model for endometriosis 2010 Volume 30 Issue 2 Pages 96-102 Details Abstract Human uterine endometrium has unique properties to regenerate and remodel cyclically throughout the woman's reproductive life and also gives rise to endometriosis through ectopic implantation of retrograde shedding including endometrial cells during menstruation. Endometriosis is a common and significant gynecological disorder which can lead to infertility or a certain type of ovarian cancer. However, the etiology and pathogenesis still remain uncertain. Previously, we have reported that singly dispersed cells isolated directly from human endometrium can reconstruct the functional ectopic endometria when transplanted beneath the kidney capsule of the NOD/SCID/γcnull immunodeficient mouse. In addition to the endometrium-like structure, hormone-dependent changes (e.g. proliferation, differentiation, tissue breakdown and shedding) characteristic of cycling human endometrium can be reproduced in the endometrial reconstruct whose blood is supplied by human-mouse chimeric vessels. These results indicate that singly dispersed endometrial cells have potential applications for tissue reconstitution, angiogenesis, and human-mouse chimeric vessel formation, providing implications for model mechanisms underlying the establishment of endometriotic lesions and the physiological endometrial regeneration during the menstrual cycle. Furthermore, the hormone-dependent behavior of the endometrium reconstructed from lentivirally-engineered endometrial cells expressing a variant luciferase can be assessed noninvasively and quantitatively by in vivo bioluminescence imaging. Our animal model will provide a powerful tool to investigate the pathophysiology of endometriosis and also to validate the effect of novel therapeutic agents and gene targeting on endometriosis with the noninvasive and real-time evaluation system. This animal system can be applied as a unique model for other various types of neoplastic diseases when the relevant cells are transplanted under the kidney capsule. This article describes our novel mouse model and in vivo imaging system with overviews of experimental models for endometriosis. © The Japanese Society of Inflammation and Regeneration Favorites & Alerts Recently viewed articles

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endometriosisinfertility

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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