An experimental model for the endometriosis in athymic mice

Siamak Tabibzadeh, S Tabibzadeh, S Miller, W C Dodson, P G Satyaswaroop
Frontiers in bioscience : a journal and virtual library · 1999 · vol. 4(1-3) , pp. c4 · doi:10.2741/tabibzad · PMID:10393127 · W2157847352
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Human endometrial cells injected into athymic mice formed ectopic adhesions on peritoneal and ovarian surfaces, demonstrating an experimental model for endometriosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 ⓘ

The paper investigated whether dissociated human endometrial cells can form ectopic adhesions when introduced into an experimental host, and used this approach to establish an endometriosis model in athymic mice. Endometrial cells from humans were suspended in peritoneal fluids from individuals with and without endometriosis, then injected intraperitoneally into nude (athymic) mice, where the cells developed ectopic adhesions on peritoneal and ovarian surfaces. Marked endometrial cells were visualized at these sites without surgery using fluorescent lipophilic dyes. The study’s main limitation is that, as an experimental model, it relies on the behavior of injected human cells in mice rather than directly recreating the full disease process in humans. This paper is centrally about endometriosis — it reports an experimental model for endometriosis in athymic mice using human endometrial cells and peritoneal fluids.

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Abstract

Endometriosis is an adhesion disorder characterized by the presence of endometrial tissue in ectopic sites outside the uterus. The disease is associated with dysmenorrhea, pelvic pain and infertility. Although endometriosis is the most common gynecologic disorder, relatively little is known regarding its etiology, pathogenesis and the course of the disease. This situation is primarily due to the absence of experimental systems to examine the mechanism of endometrial cell adhesion, role of inflammatory cells and the interactions of epithelial, and stromal cells with the peritoneum and ovarian tissue leading to the development of this disorder. Dissociated human endometrial cells were suspended in peritoneal fluids of individuals with and without endometriosis and were injected into the peritoneal cavity of athymic mice. This led to development of ectopic adhesions of endometrial cells at the peritoneal and ovarian surfaces. Endometrial cells which were marked with fluorescent lipophylic dyes, prior to intraperitoneal injection, could be visualized without surgery at such sites. The studies demonstrate a model for endometriosis in athymic mice.

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Condition tags

endometriosisdysmenorrheainfertility

MeSH descriptors

Disease Models, Animal Endometriosis Adult Animals Ascitic Fluid Ascitic Fluid Carbocyanines Endometriosis Endometrium Endometrium Female Fluorescent Dyes Humans Injections, Intraperitoneal Leukocyte Transfusion Mice Mice, Nude Microscopy, Fluorescence Middle Aged

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (19)

Cited by (23)

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