Unsuccessful Induction of Endometriosis in Female Rhesus Macaques (Macaca mulatta)

Sylvie Defrère, Jean Squifflet, Jean-Christophe Lousse, Jean‐Christophe Lousse, Anne Van Langendonckt, Reinaldo González-Ramos, Jean-Michel Foidart, Jean‐Michel Foidart, Christine Jérome, Christine Jérôme, Luc Delattre, Jacques Donnez, Jean‐Paul Dehoux, Jean-Paul Dehoux
Gynecologic and obstetric investigation · 2008 · vol. 66(2) , pp. 84–90 · doi:10.1159/000127447 · PMID:18434742 · W1996964648
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Three attempts to induce endometriosis in female rhesus macaques by transplanting endometrial tissue failed to produce any observable or histological lesions.

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Abstract

BACKGROUND/AIMS: The aim of this study was to induce endometriosis in female rhesus macaques (Macaca mulatta) for research purposes. METHODS: Three female monkeys from 4 to 4.5 years of age underwent three consecutive attempts at endometriosis induction over an 8-month period: (i) the first attempt involved intravaginal sampling of endometrial tissue and transplantation into the intrapelvic cavity; (ii) the second entailed surgical removal of endometrium after hysterotomy and intra-abdominal placement, and (iii) the third used endometrial mucosa obtained by scraping the uterus after hysterectomy, placed in a surgical pouch created in the retrovesical space (Retzius). In each case, the pelvic cavity was closely inspected after 7, 9, and 6 weeks respectively for the presence of endometriotic lesions, and peritoneal biopsies were performed. RESULTS: Neither macroscopic observation nor histological analysis revealed any endometriotic lesions. CONCLUSION: This failure to induce endometriosis in female rhesus macaques suggests that this species is not the most efficient experimental model among primates to investigate endometriosis development or treatment.

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Condition tags

endometriosis

MeSH descriptors

Disease Models, Animal Endometriosis Macaca mulatta Monkey Diseases Animals Biopsy Biopsy Endometriosis Endometriosis Female Histocytochemistry Histocytochemistry Monkey Diseases Monkey Diseases

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