Effect on Ovulation of Surgically Induced Endometriosis in Rabbits
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Surgically induced endometriosis in rabbit peritoneal cavities, but not extraperitoneal muscle, decreased ovulation by impairing follicular rupture and entrapping oocytes.
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Abstract
To study the effect of endometriosis on follicular rupture, endometrial tissue was autografted to New Zealand White rabbits. Endometrium was surgically implanted into the peritoneal cavity or into the rectus muscle. Human chorionic gonadotropin was administered to induce ovulation. During three subsequent laparotomies, the number of corpora lutea and stigmata were counted. The viability of the implants was demonstrated histologically. Ovaries were removed during the last laparotomy and ovarian serial sections were examined. In rabbits with peritoneal induced endometriosis, the percentage of stigmata/corpora lutea was significantly decreased. Macroscopic study was confirmed by histological examination. Indeed, a high incidence of entrapped oocytes was found in rabbits with peritoneal endometriosis. Extraperitoneal endometriosis had no effect on ovulation. Our data demonstrated that endometriosis induced a failure of follicular rupture. After endometriumectomy, no failure to ovulate was observed, suggesting that the effect of endometriosis on the ovulation disappeared with excision of endometrial implants.
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Cited by (12)
- Spontaneous Ovulation in Patients with Endometriosis 2024
- Effect of Genistein on Endometriosis Lesion, Matrix Metalloproteinase-2 and -9 Level of Endometriosis: In silico and In vivo Study 2016
- Unsuccessful Induction of Endometriosis in Female Rhesus Macaques <i>(Macaca mulatta)</i> 2008
- Expression und Regulation von Enzymen des Östrogenmetabolismus in humanen Endometriumläsionen kultiviert in der Nacktmaus 2007
- Quantification of endometriotic lesions in a murine model by fluorimetric and morphometric analyses 2005
- Pathogenesis of Endometriosis 2003
- Transplantation of cultured explants of human endometrium into nude mice 2000
- Peritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities 1997
- Clinical relevance of the baboon as a model for the study of endometriosis 1997
- Endometriosis and infertility 1991
- Lack of effect of peritoneal endometriosis on fertility in the rabbit model 1991
- Endometriosis as a Cause of Infertility 1989
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- europepmc
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- openalex
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