Lack of effect of peritoneal endometriosis on fertility in the rabbit model

Gerard A.J. Dunselman, Dunselman GA, G A Dunselman, Dumoulin JC, J C Dumoulin, John C.M. Dumoulin, Land JA, J A Land, Jolande A. Land, J L Evers, J.L.H. Evers
Fertility and Sterility · 1991 · vol. 56(2) , pp. 340–342 · doi:10.1016/s0015-0282(16)54496-3 · PMID:2070863 · W10854839
article OA: closed CC0 ⤵ 13 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-07, 2026-07-11 ⓘ

In an adhesion-free rabbit model, peritoneal endometriosis implants did not significantly affect fertility parameters including ovulation, fertilization, and embryonic development.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Study objectiveTo study the isolated influence of peritoneal endometrial implants on fertility in an adhesion-free rabbit model.Study designThirty-two rabbits with endometrium implants were used; 31 rabbits with fat implants served as controls. In these rabbits parameters of early embryonic development were investigated.ResultsNo significant differences were noted in ovulation, ovum pick-up, fertilization, tubal transport, and embryonic and fetal development.ConclusionIn the adhesion-free rabbit model, peritoneal implants of endometriosis do not have an effect on fertility. This supports the contention that therapies focused toward the implants are unlikely to change the pregnancy outcomes. Alternatively, it may cast doubts onto the relevance of animal models in studying this disease.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Embryonic and Fetal Development Endometriosis Fertility Peritoneal Neoplasms Animals Endometriosis Endometriosis Female Fertilization Infertility, Female Infertility, Female Ovulation Peritoneal Neoplasms Peritoneal Neoplasms Rabbits

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (9)

Cited by (13)

Source provenance

europepmc
last seen: 2026-07-26T06:08:39.051465+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:11:54.876058+00:00
License: CC0 · commercial use OK