A Rabbit Model of Endometriosis

G A Dunselman, G.A.J. Dunselman, D Willebrand, J A Land, P. X. J. M. Bouckaert, P X Bouckaert, J L Evers, J.L.H. Evers
Gynecologic and obstetric investigation · 2010 · vol. 27(1) , pp. 29–33 · doi:10.1159/000293611 · PMID:2920970 · W2072263787
article OA: closed CC0 ⤵ 11 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Rabbit endometrial implants transplanted into the peritoneal cavity formed cystic structures resembling endometriosis, proving suitable for studying fertility effects without hormonal supplementation.

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Abstract

Since not all problems in endometriosis can be studied in the human, there is need of an animal model. We transplanted endometrial tissue of the rabbit into the peritoneal cavity and studied the changes after 12 weeks. At that time the endometrial implants in the rabbit had become cystic structures. The macroscopic and histologic appearance was consistent with endometriosis. Hormonal supplementation turned out not to be necessary. Microsurgical techniques prevented the formation of tubo-ovarian adhesions. This makes the rabbit model suitable for studying the influence of endometrial implants on fertility.

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Condition tags

endometriosis

MeSH descriptors

Disease Models, Animal Endometriosis Peritoneal Neoplasms Animals Endometriosis Endometriosis Endometrium Endometrium Female Infertility, Female Infertility, Female Peritoneal Neoplasms Peritoneal Neoplasms Peritoneum Peritoneum Rabbits Tissue Adhesions

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (11)

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License: CC0 · commercial use OK