Identification of rhesus macaques with spontaneous endometriosis

Marian K. Rippy, Rippy MK, M K Rippy, Lee DR, D R Lee, Stuart Pearson, S L Pearson, Pearson SL, Bernal JC, J C Bernal, Kuehl TJ, Thomas J. Kuehl, T J Kuehl
Journal of medical primatology · 1996 · vol. 25(5) , pp. 346–355 · doi:10.1111/j.1600-0684.1996.tb00027.x · PMID:9029399 · W2075710770
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Endometriosis was diagnosed in rhesus macaques using reproductive histories, CA-125 levels, imaging, laparoscopy, and histology, identifying common disease locations and confirming the macaque as a model for studying this condition.

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Abstract

Rhesus macaques (Macaca mulatta) with endometriosis were identified using reproductive histories, serum levels CA-125, pelvic ultrasonography, laparoscopy, and histopathology. All animals were evaluated from a large breeding colony and had a history of infertility and/ or spontaneous abortions. Laparoscopy and ultrasonography were performed on 40 macaques: 27 macaques from the breeding colony with elevated CA-125 levels, ten macaques from the breeding colony with normal or low serum CA-125 levels, and three macaques from another facility with previously diagnosed spontaneous endometriosis. Clinical endometriosis was diagnosed by laparoscopy in 16/37 (43%) macaques from the breeding colony and was confirmed by histologic examination in all animals biopsied. The disease was classified as minimal (40%), mild (25%), moderate (10%), or severe (25%). The most common sites of endometriosis were the serosal surface of the uterus (75%) and the posterior cul-de-sac (75%). In this study, CA-125 levels were useful in identifying animals from the breeding colony with endometriosis. The rhesus macaque provides a valuable animal model to study endometriosis and potentially to assess efficacy of therapeutic agents for this disease condition.

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Condition tags

endometriosisinfertility

MeSH descriptors

Disease Models, Animal Endometriosis Macaca mulatta Animals CA-125 Antigen CA-125 Antigen Endometriosis Endometriosis Endometriosis Female Laparoscopy Laparoscopy Pelvis Pelvis Prevalence Ultrasonography

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