Journal of medical primatology

Intravascular adenomyosis was discovered in a cynomolgus macaque, a previously unreported presentation of adenomyosis in non-human primates that points to vascular involvement in adenomyosis etiology. Uterus gross exam was unremarkable, but…

BACKGROUND: Endometriosis is the presence of endometrium-like tissue outside the uterine cavity. An experimental model of endometriosis has been created in the baboon by the transcervical collection and laparoscopic inoculation of menstrual…

Spontaneous endometriosis is common in women, great apes and Old World monkeys, but rare in New World monkeys. We report on the clinical diagnosis and successful combination of surgical and medical treatment in a case of spontaneous endomet…

BackgroundAlthough medroxyprogesterone acetate (MPA) is used commonly as a contraceptive in women and female non-human primates, its effects on social behavior remain unclear. This study examined whether MPA treatment and introduction of ne…

Abstract Disorders of sexual development are rare in non‐human primates. We report a case of true hermaphroditism in a 19‐year‐old, nulliparous, female baboon ( Papio spp.). At necropsy, the animal was obese with adequate muscle mass and hy…

BackgroundWe evaluated whether menstrual cycle phase influences the assessment of tubal patency by hysterosalpingography (HSG) in baboons.MethodsRetrospective analysis of baseline tubal patency studies and serum estradiol (E2 ) and progeste…

We present the spontaneous pathological lesions identified as a result of necropsy or biopsy for 245 chimpanzees (Pan troglodytes) over a 35-year period. A review of the pathology database was performed for all diagnoses on chimpanzees from…

BackgroundLong-acting, hormonal contraception may increase HIV risk. Copper intrauterine devices (IUDs) could serve as non-hormonal alternatives. We pilot a pigtail macaque model for evaluating HIV susceptibility factors during copper IUD u…

BackgroundWe report the causes of mortality for 4350 captive baboons that died or were euthanized due to natural causes during a 23 year period at the Southwest National Primate Research Center.MethodsNecropsy records were retrieved and rev…

Background and methodsA reservoir intravaginal ring (IVR) eluting tenofovir disoproxil fumarate (TDF) was evaluated for 6 months of continuous use in normally cycling female pigtailed macaques with monthly IVR exchanges to define pharmacoki…

BACKGROUND: As endometriosis is known to be very painful in humans, therapeutic studies should consider pain-related aspects in experimental animals too. In a previous study, we found that common marmosets suffering from endometriosis show …

Abstract Background Human pleuro‐pulmonary endometriosis ( PPE ) is rare. Recently, we identified several cases of abdominal endometriosis in baboons that developed PPE . Materials and Methods Ten cases of PPE and four of intra‐abdominal en…

BACKGROUND: As common marmosets (Callithrix jacchus) are frequently used experimental animals, sensitive test systems are needed to evaluate impairment and pain caused by procedures and diseases. METHODS: A diurnal profile of healthy animal…

BackgroundBaboons are useful animal models for biomedical research, but the natural pathology of the baboon is not as well defined as other non-human primates.MethodsA computer search for all morphologic diagnoses from baboon necropsies at …

BACKGROUND: Ovarian pathology is an important cause of decreased fertility and reproductive capability and may impact multiple systems, particularly in aging rhesus macaques. METHODS: Retrospective histopathologic and immunohistochemical a…

BACKGROUND: Endometrial and cervical polyps are masses of endometrium or cervical epithelium that bulge into the uterine or cervical lumen. The physiopathology and contributing factors of endometrial polyps development are still unknown. ME…

BackgroundGastrointestinal stromal tumors (GISTs) are believed to originate from the intestinal pacemaker cells (interstitial cells of Cajal) or their progenitor cells. Spontaneous tumors have been reported in dogs, horses, rhesus, and a ch…

BackgroundCases of abdominal pregnancy, in the form of intra-abdominal mummified fetuses, have been described in nonhuman primates. Gestational diabetes and pre-eclampsia are common pregnancy complications in women.MethodsTwo timed-bred rhe…

BackgroundPrimary neuroendocrine carcinomas of the liver have rarely been reported in humans and domestic animals, but not in non-human primates.MethodsWe describe the morphologic and immunohistochemical features of a primary hepatic neuroe…

BACKGROUND: Marmosets and tamarins are increasingly used in research, but their pathology remains poorly defined compared with Old World primates. METHODS: Necropsy records of 129 marmosets and 52 tamarins were reviewed; none was used expe…

BACKGROUND: Endometriosis is a condition where endometrium-like tissue forms lesions at ectopic sites outside the uterus. In women, oral contraceptive pills and progestins are often prescribed as therapy for early stage endometriosis. In co…

BackgroundIn baboons, Papio sp. neoplasms tend to affect the hematopoietic system most commonly, with rare documentation of myxomatous neoplasms. In contrast, women can develop myxomatous masses within deep peripelvic tissues with some freq…

Abstract Background Spontaneous reproductive tract abnormalities occurred in six female wild‐caught, Philippine‐origin, Macaca fascicularis . These animals were between 19 and 22 years of age and maintained in captivity for approximately 15…

The National Institute on Aging (NIA) sponsored a workshop on September 8, 2004, to discuss the incidence, diagnosis, and clinical treatment of endometriosis in rhesus monkey colonies. Because of the growing number of aging studies using rh…

Spontaneous endometriosis was diagnosed in 43 baboons over a 14-year period. Thirty-seven have died; five remain alive; one was sold and lost to follow-up. The average age at diagnosis was 17.2 years; 29 (67%) were between 12 and 21 years o…