Pharmacokinetic evaluation of tenofovir disoproxil fumarate released from an intravaginal ring in pigtailed macaques after 6 months of continuous use.

Srinivasan P; Dinh C; Zhang J; Pau CP; McNicholl JM; Lo Y; Herold BC; Teller R; Kiser P; Smith JM

doi:10.1111/jmp.12119

Pharmacokinetic evaluation of tenofovir disoproxil fumarate released from an intravaginal ring in pigtailed macaques after 6 months of continuous use.

Srinivasan P, Dinh C, Zhang J, Pau CP, McNicholl JM, Lo Y, Herold BC, Teller R, Kiser P, Smith JM

Journal of medical primatology · 2014 · doi:10.1111/jmp.12119 · PMID:25379594 · PMC4226177

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Abstract

Background and methodsA reservoir intravaginal ring (IVR) eluting tenofovir disoproxil fumarate (TDF) was evaluated for 6 months of continuous use in normally cycling female pigtailed macaques with monthly IVR exchanges to define pharmacokinetics and safety.Results and conclusionsTenofovir levels in vaginal secretions and tissue remained consistent for 6 months with no adverse safety concerns.

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