Behavioral tests as indicator for pain and distress in a primate endometriosis model

Caroline Arnold, C Arnold, Jessica da Silva Lamp, J Lamp, Ole Lamp, O Lamp, A Einspanier
Journal of medical primatology · 2011 · vol. 40(5) , pp. 317–326 · doi:10.1111/j.1600-0684.2011.00496.x · PMID:21950721 · W2123334788
article OA: closed CC0 ⤵ 3 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Behavioral tests including videotaping and the Wisconsin General Test Apparatus identified decreased social grooming, activity, and poorer cognitive habituation in common marmosets with endometriosis compared to healthy controls.

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Abstract

BACKGROUND: As common marmosets (Callithrix jacchus) are frequently used experimental animals, sensitive test systems are needed to evaluate impairment and pain caused by procedures and diseases. METHODS: A diurnal profile of healthy animals was obtained by videotaping. Differences in social behavior and cognitive skills between marmosets with established endometriosis and healthy monkeys were investigated using the videotaping, the Wisconsin General Test Apparatus (WGTA), and a food tree. RESULTS: The marmosets showed a mostly trimodal course of activity. Social grooming and activity were significantly decreased in animals with endometriosis; furthermore, the diseased monkeys habituated significantly worse to the cognitive test settings. The food tree experiments offered no differences between diseased and control animals. CONCLUSION: The videotaping and the WGTA are suitable methods to detect disease-related impairments in common marmosets, which is essential for the refinement of experiments.

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Condition tags

endometriosis

MeSH descriptors

Animals, Laboratory Behavior, Animal Callithrix Endometriosis Monkey Diseases Pain Pain Measurement Videotape Recording Animals Animals, Laboratory Animal Welfare Callithrix Disease Models, Animal Endometriosis Endometriosis Female Habituation, Psychophysiologic Male Monkey Diseases Pain

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (29)

Cited by (3)

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