Medical treatment improves social behavior in a primate endometriosis model (Callithrix jacchus)

Arnold C, C Arnold, Caroline Arnold, A. Einspanier, Einspanier A
Journal of medical primatology · 2013 · vol. 42(3) , pp. 112–119 · doi:10.1111/jmp.12042 · PMID:23432639 · W2030296049
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Medical treatment for endometriosis in marmosets significantly improved social and self-grooming behaviors, restoring them to levels comparable to healthy animals.

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Abstract

BACKGROUND: As endometriosis is known to be very painful in humans, therapeutic studies should consider pain-related aspects in experimental animals too. In a previous study, we found that common marmosets suffering from endometriosis show remarkable deviations in social behavior and cognitive tasks. METHODS: Female marmosets with endometriosis undergoing medical treatment were tested vs. two control groups (healthy and endometriosis monkeys without treatment) concerning behavioral aspects, cognitive skills, and mobility. RESULTS: The treated monkeys performed significant more social and self-grooming, comfort behavior and were more active than the untreated endometriosis monkeys. The treated marmosets even returned to equal levels as their healthy conspecifics. Cognitive and mobility tests revealed no significant differences. CONCLUSIONS: A beneficial effect of the applied endometriosis medication on behavioral impairments could be obtained. Including such measurements in therapeutic research contributes to aspects of animal welfare and pain-relieving potential of the tested compound.

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Condition tags

endometriosis

MeSH descriptors

17-Hydroxysteroid Dehydrogenases Callithrix Cognition Endometriosis Social Behavior 17-Hydroxysteroid Dehydrogenases Animals Disease Models, Animal Endometriosis Endometriosis Female Grooming Motor Activity Pain Videotape Recording

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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