Medical treatment improves social behavior in a primate endometriosis model (Callithrix jacchus)

Arnold C, C Arnold, Caroline Arnold, A. Einspanier, Einspanier A
Journal of medical primatology · 2013 · vol. 42(3) , pp. 112–119 · doi:10.1111/jmp.12042 · PMID:23432639 · W2030296049
Lab / animal OA: closed CC0 ⤵ 3 in-corpus citations
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Medical treatment for endometriosis in marmosets significantly improved social and self-grooming behaviors, restoring them to levels comparable to healthy animals.

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Abstract

BACKGROUND: As endometriosis is known to be very painful in humans, therapeutic studies should consider pain-related aspects in experimental animals too. In a previous study, we found that common marmosets suffering from endometriosis show remarkable deviations in social behavior and cognitive tasks. METHODS: Female marmosets with endometriosis undergoing medical treatment were tested vs. two control groups (healthy and endometriosis monkeys without treatment) concerning behavioral aspects, cognitive skills, and mobility. RESULTS: The treated monkeys performed significant more social and self-grooming, comfort behavior and were more active than the untreated endometriosis monkeys. The treated marmosets even returned to equal levels as their healthy conspecifics. Cognitive and mobility tests revealed no significant differences. CONCLUSIONS: A beneficial effect of the applied endometriosis medication on behavioral impairments could be obtained. Including such measurements in therapeutic research contributes to aspects of animal welfare and pain-relieving potential of the tested compound.

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Condition tags

endometriosis

MeSH descriptors

17-Hydroxysteroid Dehydrogenases Callithrix Callithrix Cognition Cognition Endometriosis Social Behavior Social Behavior 17-Hydroxysteroid Dehydrogenases 17-Hydroxysteroid Dehydrogenases Animals Animals Disease Models, Animal Disease Models, Animal Endometriosis Endometriosis Endometriosis Female Female Grooming

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (34)

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