An irreversible inhibitor of 17β-hydroxysteroid dehydrogenase type 1 inhibits estradiol synthesis in human endometriosis lesions and induces regression of the non-human primate endometriosis

Donald Poirier, Atunga Nyachieo, Andrea Romano, Jenny Roy, René Maltais, Daniel Chai, Bert Delvoux, Carla Tomassetti, Arne Vanhie
The Journal of steroid biochemistry and molecular biology · 2022 · vol. 222 , pp. 106136 · doi:10.1016/j.jsbmb.2022.106136 · PMID:35691460 · W4282940052
article OA: closed CC0 ⤵ 5 in-corpus citations
Limited metadata. Only one source feed has indexed this record so far — no abstract, full text, or open-access copy is available through Endo Lab. The publisher's page (linked below) is the canonical location for the actual content. If you have institutional access, use "Find at my library".
View at publisher → View on OpenAlex View on PubMed
⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This study investigated an irreversible inhibitor of 17β-hydroxysteroid dehydrogenase type 1, finding it reduces estradiol synthesis in human endometriosis lesions and promotes regression in non-human primate endometriosis models.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

My notes (saved in your browser only)

Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Estradiol Estradiol Estradiol Estradiol Estradiol Estradiol Estradiol Estradiol Estradiol

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (35)

Cited by (5)

Source provenance

europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-26T00:34:42.998379+00:00
License: CC0 · commercial use OK