Spontaneous Ovulation in Patients with Endometriosis

Approximately 20 years ago, studies performed in the animal model of endometriosis suggested that endometrial autografts placed throughout the pelvic peritoneum caused infertility by interfering with ovulation. Based on this background, some studies investigated if ovarian endometrioma influenced the frequency of ovulation in the affected ovary. Initial studies suggested that ovulation occurs less frequently in ovaries with endometriomas. However, more recently, a prospective Italian study including 244 women with unilateral endometriomas demonstrated that ovulation is not affected by the presence of endometrioma and that the number and the size of endometriomas do not influence ovulation. Endometriosis may impair fertility through multiple pathways, including peritoneal inflammation, endocrine derangements that reduce oocyte competence, and decreased endometrial receptivity; however, it does not seem to affect spontaneous ovulation significantly. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others

Maggiore ULR, Gupta JK, Ferrero S. Treatment of endometrioma for improving fertility. Eur J Obstet Gynecol Reprod Biol. 2017;209:81–5. Sanchez AM, et al. The distinguishing cellular and molecular features of the endometriotic ovarian cyst: from pathophysiology to the potential endometrioma-mediated damage to the ovary. Hum Reprod Update. 2014;20(2):217–30. Schenken RS, Asch RH. Surgical induction of endometriosis in the rabbit: effects on fertility and concentrations of peritoneal fluid prostaglandins. Fertil Steril. 1980;34(6):581–7. Schenken RS, et al. Etiology of infertility in monkeys with endometriosis: luteinized unruptured follicles, luteal phase defects, pelvic adhesions, and spontaneous abortions. Fertil Steril. 1984;41(1):122–30. Donnez J, et al. Effect on ovulation of surgically induced endometriosis in rabbits. Gynecol Obstet Investig. 1987;24(2):131–7. Kaplan CR, et al. Effect of ovarian endometriosis on ovulation in rabbits. Am J Obstet Gynecol. 1989;160(1):40–4. Soules MR, et al. Endometriosis and anovulation: a coexisting problem in the infertile female. Am J Obstet Gynecol. 1976;125(3):412–7. Mahmood TA, Templeton A. Folliculogenesis and ovulation in infertile women with mild endometriosis. Hum Reprod. 1991;6(2):227–31. Holoch KJ, et al. Endometriosis in women with polycystic ovary syndrome (PCOS) and its role in poor reproductive outcomes. Fertil Steril. 2011;96(3):S133. Hager M, et al. The prevalence of incidental endometriosis in women undergoing laparoscopic ovarian drilling for clomiphene-resistant polycystic ovary syndrome: a retrospective cohort study and meta-analysis. J Clin Med. 2019;8:8. Santulli P, et al. Oligo-anovulation is not a rarer feature in women with documented endometriosis. Fertil Steril. 2018;110(5):941–8. Maneschi F, et al. Ovarian cortex surrounding benign neoplasms: a histologic study. Am J Obstet Gynecol. 1993;169(2 Pt 1):388–93. Horikawa T, et al. The frequency of ovulation from the affected ovary decreases following laparoscopic cystectomy in infertile women with unilateral endometrioma during a natural cycle. J Assist Reprod Genet. 2008;25(6):239–44. Benaglia L, et al. Endometriotic ovarian cysts negatively affect the rate of spontaneous ovulation. Hum Reprod. 2009;24(9):2183–6. Maggiore ULR, et al. Endometriotic ovarian cysts do not negatively affect the rate of spontaneous ovulation. Hum Reprod. 2015;30(2):299–307. Lagana AS, et al. Anxiety and depression in patients with endometriosis: impact and management challenges. Int J Women's Health. 2017;9:323–30. Kalantaridou SN, et al. Stress and the female reproductive system. J Reprod Immunol. 2004;62(1–2):61–8. Attar E, et al. Increased concentration of vascular endothelial growth factor in the follicular fluid of patients with endometriosis does not affect the outcome of in vitro fertilization-embryo transfer. Fertil Steril. 2003;80(6):1518–20. Pocate-Cheriet K, et al. The follicular fluid metabolome differs according to the endometriosis phenotype. Reprod Biomed Online. 2020;41(6):1023–37. Tanbo T, Fedorcsak P. Endometriosis-associated infertility: aspects of pathophysiological mechanisms and treatment options. Acta Obstet Gynecol Scand. 2017;96(6):659–67. Author information Authors and Affiliations Corresponding author Editor information Editors and Affiliations Rights and permissions Copyright information © 2024 The Author(s), under exclusive license to Springer Nature Switzerland AG About this chapter Cite this chapter Ferrero, S., Barra, F., Crosa, M., Leone Roberti Maggiore, U., Attar, H. (2024). Spontaneous Ovulation in Patients with Endometriosis. In: Ferrero, S. (eds) Endometriosis-related Infertility. Springer, Cham. https://doi.org/10.1007/978-3-031-50662-8_5 Download citation DOI: https://doi.org/10.1007/978-3-031-50662-8_5 Published: Publisher Name: Springer, Cham Print ISBN: 978-3-031-50661-1 Online ISBN: 978-3-031-50662-8 eBook Packages: MedicineMedicine (R0)