Animal models of endometriosis: Replicating the aetiology and symptoms of the human disorder

Ioannis Simitsidellis, Douglas A Gibson, Philippa T K Saunders
Best practice & research. Clinical endocrinology & metabolism · 2018 · vol. 32(3) , pp. 257–269 · doi:10.1016/j.beem.2018.03.004 · PMID:29779580 · W2796336781
review OA: green CC0 ⤵ 28 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

This review discusses validated primate, rodent, and xenograft animal models that replicate endometriosis aetiology and symptoms, aiding understanding and therapeutic intervention development.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 ⓘ

This review paper evaluates validated animal models used to replicate key features of human endometriosis, including their ability to model aspects of aetiology and symptoms such as chronic pain and infertility. The authors describe several model types—primate, rodent, and xenograft—and summarize how evidence from these models has informed understanding of mechanisms underpinning symptom development and supported preclinical drug testing. A key caveat, as framed in the paper, is that because endometriosis aetiology remains poorly understood and new non-surgical therapies are urgently needed, model development and validation are necessary steps for reliable therapeutic assessment. This paper is centrally about endometriosis — it reviews animal models (primate, rodent, xenograft) for replicating endometriosis aetiology and symptoms to support therapy validation.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

My notes (saved in your browser only)

Condition tags

endometriosischronic_pelvic_pain

MeSH descriptors

Chronic Pain Chronic Pain Chronic Pain Disease Models, Animal Endometriosis Endometriosis Infertility, Female Infertility, Female Animals Endometriosis Female Heterografts Humans Pelvic Pain Pelvic Pain Pelvic Pain Primates Prodromal Symptoms Rodentia

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Cited by (28)

Source provenance

europepmc
last seen: 2026-06-13T06:22:48.782012+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:19:49.066213+00:00
License: CC0 · commercial use OK