An overview and comprehensive analysis of interdisciplinary clinical research in endometriosis based on trial registry

Yicong Xu, Zhengrong Deng, Fan Fei, Shengtao Zhou
iScience · 2024 · vol. 27(3) , pp. 109298 · doi:10.1016/j.isci.2024.109298 · PMID:38455973 · W4391957739
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This analysis of ClinicalTrials.gov identified that 30% of endometriosis trials are interdisciplinary, showing growth in multidisciplinary and collaborative research but facing challenges with randomization and results reporting compared to traditional trials.

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Abstract

Endometriosis is a chronic multisystem disease associated with immunological, genetic, hormonal, psychological, and neuroscientific factors, leading to a significant socioeconomic impact worldwide. Though multidisciplinary management is the ideal approach, there remains a scarcity of published interdisciplinary clinical trials at present. Here, we have conducted a comprehensive analysis of the characteristics and issues of interdisciplinary trials on endometriosis based on the clinical registration database ClinicalTrials.gov. Among all 387 endometriosis trials, 30% (116) were identified as interdisciplinary, mostly conducted in Europe and North America, and fully funded by non-industrial sources. We documented growth in both patient-centered multidisciplinary comprehensive management and collaboration between fundamental biomedical science and applied medicine. However, compared to traditional obstetric-gynecological trials, interdisciplinary studies exhibited negative characteristics such as less likely to be randomized and less likely to report results. Our study provides insights for future trial investigators and may contribute to fostering greater collaboration in medical research.

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endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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