Neuropeptide S receptor 1 is a nonhormonal treatment target in endometriosis

Thomas T. Tapmeier, Nilüfer Rahmioğlu, Jianghai Lin, Lin J, De Leo B, Bianca De Leo, Maik Obendorf, Muthuswamy Raveendran, Fischer OM, Oliver M. Fischer, Cemsel Bafligil, Manman Guo, R. Alan Harris, Holger Hess‐Stumpp, Alexis Laux‐Biehlmann, Alexis Laux-Biehlmann, Ernesto Lowy, Gerton Lunter, Jessica Malzahn, Nicholas G. Martin, Fernando O. Martínez, Sanjiv Manek, Manek S, Mesch S, Stefanie Mesch, Grant W. Montgomery, Montgomery GW, Andrew P. Morris, Jens Nagel, Heather A. Simmons, Denise Brocklebank, Brocklebank D, Catherine A. Shang, Susan A. Treloar, Wells G, Graham Wells, Christian M. Becker, Becker CM, Udo Oppermann, Thomas M. Zollner, Stephen Kennedy, Joseph W. Kemnitz, Jeffrey Rogers, Krina T. Zondervan
Science translational medicine · 2021 · vol. 13(608) · doi:10.1126/scitranslmed.abd6469 · PMID:34433639 · W3194699388
article OA: closed CC0 ⤵ 22 in-corpus citations
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

Neuropeptide S receptor 1 antagonism reduced peritoneal inflammation and endometriosis development in mouse models, identifying it as a potential nonhormonal therapeutic target.

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Abstract

< 0.05) in a mouse model of peritoneal inflammation as well as in a mouse model of endometriosis. We conclude that the NPSR1/NPS system is a genetically validated, nonhormonal target for the treatment of endometriosis with likely increased relevance to stage III/IV disease.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Receptors, G-Protein-Coupled Animals Endometrium Female Humans Macaca mulatta Mice Receptors, G-Protein-Coupled Tumor Necrosis Factor-alpha

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (60)

Cited by (28)

Source provenance

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License: CC0 · commercial use OK