World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project: V. Physical examination standards in endometriosis research

Tinya Lin, Catherine Allaire, Sawsan As‐Sanie, Sawsan As-Sanie, Pamela Stratton, Katy Vincent, G David Adamson, Lars Arendt‐Nielsen, Lars Arendt-Nielsen, Deborah Bush, Femke Jansen, Jennifer Longpre, Luk Rombauts, Jay Shah, Abeesha Toussaint, Lone Hummelshøj, Lone Hummelshoj, Stacey A Missmer, Paul J Yong, Elisabet Andersson, WERF EPHect Physical Examination Working Group, Jorge F. Carrillo, Emma Cox, Hale Göksever Çelik, Andrew W. Horne, Amanda James, Akaiti James, Georgine Lamvu, Dan C. Martin, Olivia C. Nwankudu, Frank F. Tu
Fertility and sterility · 2024 · vol. 122(2) , pp. 304–315 · doi:10.1016/j.fertnstert.2024.03.007 · PMID:38508508 · W4392968454
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

The Endometriosis Phenome and Biobanking Harmonisation Project developed standardized physical examination standards to document endometriosis characteristics and associated pain for research studies.

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Abstract

OBJECTIVE: The World Endometriosis Research Foundation established the Endometriosis Phenome and Biobanking Harmonisation Project (EPHect) to create standardized documentation tools (with common data elements) to facilitate the comparison and combination of data across different research sites and studies. In 2014, 4 data research standards were published: clinician-reported surgical data, patient-reported clinical data, and fluid and tissue biospecimen collection. Our current objective is to create an EPHect standard for the clinician-reported physical examination (EPHect-PE) for research studies. DESIGN: An international consortium involving 26 clinical and academic experts and patient partners from 11 countries representing 25 institutions and organizations. Two virtual workshops, followed by the development of the physical examination standards underwent multiple rounds of iterations and revisions. SUBJECTS: N/A MAIN OUTCOME MEASURE(S): N/A RESULT(S): The EPHect-PE tool provides standardized assessment of physical examination characteristics and pain phenotyping. Data elements involve examination of back and pelvic girdle; abdomen including allodynia and trigger points; vulva including provoked vestibulodynia; pelvic floor muscle tone and tenderness; tenderness on unidigital pelvic examination; presence of pelvic nodularity; uterine size and mobility; presence of adnexal masses; presence of incisional masses; speculum examination; tenderness and allodynia at an extra-pelvic site (e.g., forearm); and recording of anthropometrics. CONCLUSION(S): The EPHect-PE standards will facilitate the standardized documentation of the physical examination, including the assessment and documentation of examination phenotyping of endometriosis-associated pelvic pain.

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Condition tags

endometriosischronic_pelvic_pain

MeSH descriptors

Biological Specimen Banks Biological Specimen Banks Biological Specimen Banks Biological Specimen Banks Biological Specimen Banks Biological Specimen Banks Biological Specimen Banks Biomedical Research Biomedical Research Biomedical Research Biomedical Research Biomedical Research Biomedical Research Biomedical Research Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

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