Laparoscopic Surgery: A New Technique to Induce Endometriosis in a Mouse Model

Daniëlle Peterse, Daniëlle P Peterse, Amelie Fassbender, Dorien F O, F. O. Dorien, Arne Vanhie, Philippa T. K. Saunders, Philippa Saunders, Joris Vriens, M Mercedes Binda, María Mercedes Binda, Thomas D’Hooghe, Thomas M D'Hooghe
Reproductive sciences (Thousand Oaks, Calif.) · 2016 · vol. 23(10) , pp. 1332–1339 · doi:10.1177/1933719116638178 · PMID:26994066 · W2321113022
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-09 ⓘ

This study successfully induced endometriosis in 100% of recipient mice using laparoscopic inoculation of uterine pieces, achieving a 60% implant take rate without significant differences between anesthetic or insufflation pressure groups.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This prospective pilot study evaluated whether endometriosis could be induced in mice using laparoscopic surgery rather than laparotomy, aiming for a peritoneal implant take rate of at least 50% by varying anesthesia duration (ketamine/xylazine vs pentobarbital) and intra-abdominal pressure (5 vs 15 mm Hg). Female BALB/c mice served as uterine tissue donors and laparoscopically inoculated recipients (10 uterine pieces per mouse), with endometriosis incidence and implant take assessed one week later by visual documentation and histology of retrieved lesions. Laparoscopic inoculation produced 100% endometriosis incidence (20/20) and an individual peritoneal implant take rate of 60% (121/206), with histological confirmation in 92% (58/63) of analyzed lesions, and the authors reported no differences across the four subgroups. This paper is centrally about endometriosis in an animal model—specifically establishing laparoscopic induction of endometriosis in rodents.

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Condition tags

endometriosis

MeSH descriptors

Disease Models, Animal Endometriosis Endometriosis Endometriosis Laparoscopy Animals Estrous Cycle Female Laparoscopy Mice Mice, Inbred BALB C Peritoneal Cavity Peritoneal Cavity Pilot Projects Prospective Studies

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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