Etiology of infertility in monkeys with endometriosis: Measurement of peritoneal fluid prostaglandins

Robert S. Schenken, Schenken RS, R S Schenken, Asch RH, R H Asch, Ricardo H. Asch, Williams RF, Robert F. Williams, R F Williams, Hodgen GD, G. D. Hodgen, Gary D. Hodgen
American journal of obstetrics and gynecology · 1984 · vol. 150(4) , pp. 349–353 · doi:10.1016/s0002-9378(84)80136-2 · PMID:6592974 · W1998173257
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This study measured prostaglandin levels in peritoneal fluid of monkeys with endometriosis to investigate the etiology of their infertility.

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Abstract

To study the relationship between peritoneal fluid prostaglandins and infertility associated with endometriosis, we autografted endometrial or adipose tissue to the pelvic peritoneum in 21 monkeys. Peritoneal washings were collected prior to tissue transplantation and during a subsequent laparotomy performed for biopsy of the implants. Monkeys were mated and peritoneal washings were collected during three subsequent cycles. The content of prostaglandin F2 alpha (PGF2 alpha) in adipose tissue autografts was significantly less (p less than 0.05) than in endometrial tissue autografts. The PGF2 alpha concentration in peritoneal fluid increased significantly (p less than 0.05) only in monkeys that developed moderate or severe endometriosis. Prostaglandin E levels in tissue autografts or peritoneal fluid were similar in all animals. Infertility in monkeys with endometriosis was associated with luteinized unruptured follicles, luteal phase defects, and pelvic adhesions. Although PGF2 alpha concentrations in peritoneal washings obtained during these cycles were increased in comparison with those of ovulatory cycles, the difference was not significant. A relationship between spontaneous abortion and prostaglandin concentrations in peritoneal fluid was not established.

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Condition tags

endometriosisinfertility

MeSH descriptors

Body Fluids Endometriosis Infertility, Female Prostaglandins E Prostaglandins F Animals Body Fluids Dinoprost Endometriosis Endometriosis Female Infertility, Female Infertility, Female Macaca fascicularis Menstrual Cycle Peritoneum Pregnancy Prostaglandins E Prostaglandins F

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