Experimental adenomyosis

Greaves P, Peter Greaves, Ian N H White, White IN
Best practice & research. Clinical obstetrics & gynaecology · 2006 · vol. 20(4) , pp. 503–510 · doi:10.1016/j.bpobgyn.2006.01.003 · PMID:16500151 · W4210396097
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This paper describes the experimental induction of adenomyosis in an animal model to investigate its pathological mechanisms.

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Abstract

Adenomyosis has been reported in a number of different animal species, whereas endometriosis appears limited to humans and non-human primates. This suggests a different aetiology of the two conditions. Adenomyosis develops spontaneously in certain strains of laboratory mice. Its incidence in mice can be markedly enhanced by systemic exposure to various hormonal agents, including prolactin, progesterone, synthetic progestins, certain oestrogenic agents, as well as tamoxifen and toremifene. The precise hormonal changes necessary remain unclear, although the evidence suggests that adenomyosis in this model is not due to a simple oestrogenic effect. Study of the pathological and molecular alterations in this model indicates that disturbances to the uterine stroma, blood vessels and myometrium are also important factors in the development of adenomyosis.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Disease Models, Animal Endometriosis Uterine Diseases Animals Cats Dogs Endometriosis Endometriosis Endometrium Endometrium Estrogen Antagonists Female Humans Mice Myometrium Myometrium Pituitary Gland Pituitary Gland Primates Progesterone

Citation neighborhood

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References (33)

Cited by (46)

Source provenance

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