Experimental adenomyosis

Greaves P, Peter Greaves, Ian N H White, White IN
Best practice & research. Clinical obstetrics & gynaecology · 2006 · vol. 20(4) , pp. 503–510 · doi:10.1016/j.bpobgyn.2006.01.003 · PMID:16500151 · W4210396097
Review OA: closed CC0 ⤵ 46 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This paper describes the experimental induction of adenomyosis in an animal model to investigate its pathological mechanisms.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Adenomyosis has been reported in a number of different animal species, whereas endometriosis appears limited to humans and non-human primates. This suggests a different aetiology of the two conditions. Adenomyosis develops spontaneously in certain strains of laboratory mice. Its incidence in mice can be markedly enhanced by systemic exposure to various hormonal agents, including prolactin, progesterone, synthetic progestins, certain oestrogenic agents, as well as tamoxifen and toremifene. The precise hormonal changes necessary remain unclear, although the evidence suggests that adenomyosis in this model is not due to a simple oestrogenic effect. Study of the pathological and molecular alterations in this model indicates that disturbances to the uterine stroma, blood vessels and myometrium are also important factors in the development of adenomyosis.

My notes (saved in your browser only)

Condition tags

endometriosisadenomyosis

MeSH descriptors

Disease Models, Animal Disease Models, Animal Endometriosis Uterine Diseases Animals Animals Cats Cats Dogs Dogs Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Estrogen Antagonists Estrogen Antagonists Female Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (33)

Cited by (47)

Source provenance

europepmc
last seen: 2026-10-14T06:08:39.101224+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:03:37.664955+00:00
License: CC0 · commercial use OK