Evaluation of the efficacy of a danazol-loaded intrauterine contraceptive device on adenomyosis in an ICR mouse model

X. Zhang, Xinmei Zhang, Yuan Huang, H. Yuan, Hong Yuan, Liping Deng, Lin Deng, Fengling Hu, Fuqiang Hu, Junyan Ma, Jing Ma, Jun Lin, Jinwen Lin
Human Reproduction · 2008 · vol. 23(9) , pp. 2024–2030 · doi:10.1093/humrep/den208 · PMID:18552364 · W2030023117
article OA: closed CC0 ⤵ 19 in-corpus citations
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This study developed a danazol-loaded intrauterine device that effectively reduced adenomyosis nodules in mice, with lower systemic danazol levels than oral administration.

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Abstract

BACKGROUND: Danazol, a synthetic steroid with antigonadotrophic properties, has been widely used for the treatment of endometriosis and adenomyosis. However, the local application of danazol to the uterus to treat adenomyosis is controversial. The objective of this study is to develop an effective treatment for adenomyosis using danazol via intrauterine contraceptive device (IUCD) delivery. METHODS: An adenomyosis animal model was established using Institute for Cancer Research, Swiss-derived (ICR) mice, grafted with a single pituitary gland (n = 30). Four months after grafting, IUCDs with three different quantities of danazol were prepared and used to treat the ICR mice with adenomyosis. After 2 months of treatment with a danazol-loaded IUCD, the number of adenomyosis nodules and the hematoxylin-eosin staining scores were measured and compared with mice given daily oral danazol and controls (no adenomyosis). RESULTS: As the danazol dose increased, the nodule number decreased reaching significance at a dose of 2.0 mg per 20 g body weight (P = 0.002). When compared with oral administration, the plasma danazol concentrations with IUCD delivery were low and stable. CONCLUSIONS: These results suggest that an IUCD loaded with an appropriate dose of danazol may be an effective treatment for adenomyosis and that human trials are warranted.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Danazol Endometriosis Estrogen Antagonists Intrauterine Devices, Medicated Animals Danazol Danazol Danazol Disease Models, Animal Endometriosis Endometriosis Estrogen Antagonists Estrogen Antagonists Estrogen Antagonists Female Mice Mice, Inbred ICR

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (34)

Cited by (19)

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