Direct effects of medroxyprogesterone acetate, danazol, and leuprolide acetate on endometrial stromal cell proliferation in vitro

Eric S. Surrey, E. S. Surrey, Surrey ES, Halme J, J Halme, Jouko Halme
Fertility and sterility · 1992 · vol. 58(2) , pp. 273–278 · doi:10.1016/s0015-0282(16)55199-1 · PMID:1386030 · W2409142888
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Medroxyprogesterone acetate, danazol, and leuprolide acetate differentially inhibit endometrial stromal cell proliferation in vitro.

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Abstract

ObjectiveTo assess the direct effects of three endometriosis chemotherapeutic agents (medroxyprogesterone acetate [MPA], danazol, and leuprolide acetate [LA]) on endometrial cell proliferation.DesignAnalysis of cell proliferation in vitro.SettingProliferative phase endometrial stromal cells isolated from biopsy specimens and grown in short-term culture served as a model for stromal components of endometriotic implants.PatientsBiopsies obtained from volunteers with regular cycles and without endometriosis or endometrial pathology.InterventionsMedroxyprogesterone acetate, danazol, and LA were added to nutrient media with the following supplements: 2.5% calf serum (CS) only; 2.5% CS+estradiol (E2) 110 pmol/L; 2.5% CS+E2 550 pmol/L; 10% preovulatory serum (net E2 624 pmol/L).Main outcome measuresCumulative [3H]-thymidine incorporation as a reflection of cell proliferation.ResultsMedroxyprogesterone acetate and danazol exerted significant antiproliferative effects on stromal cell proliferation (P less than 0.05), effects that were enhanced by an absence of exogenous E2. Leuprolide acetate exerted no consistent effects.ConclusionsThese data imply that MPA and danazol but not LA exert direct effects, suppressing growth of endometriotic implants.

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MeSH descriptors

Danazol Endometrium Leuprolide Medroxyprogesterone Adult Cell Division Cell Division Cells, Cultured Danazol DNA DNA Endometrium Female Humans Leuprolide Medroxyprogesterone Medroxyprogesterone Medroxyprogesterone Acetate

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