Induction of Endometriosis and Adenomyosis by Transvaginal Pituitary Transplantation in Mice with and without Natural Killer Cell Activity

TSUNEMARO KOUJYO, Koujyo T, T Koujyo, Hatakeyama S, S. Hatakeyama, Shigetsugu Hatakeyama, Yamada H, H Yamada, Hideto Yamada, K Iwabuchi, Kazuya Iwabuchi, Iwabuchi K, Kiichi Kajino, K Kajino, Kajino K, K. OGASAWARA, Kazumasa Ogasawara, Ogasawara K, Onoe K, K Onoe, Kazunori Onoé, S Fujimoto, Seiichiro Fujimoto, Fujimoto S
American journal of reproductive immunology (New York, N.Y. : 1989) · 1998 · vol. 40(6) , pp. 441–446 · doi:10.1111/j.1600-0897.1998.tb00431.x · PMID:9894569 · W1986008418
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Transvaginal pituitary transplantation in mice induced endometriosis and adenomyosis, with reduced natural killer cell activity not appearing necessary for primary development.

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Abstract

PROBLEM: The aims of this study were to establish a mouse model of endometriosis and adenomyosis and to elucidate the necessity of reduced natural killer (NK)-cell and T-cell activities in the establishment of endometriosis and adenomyosis. METHOD OF STUDY: Pituitary glands, submandibular glands, a hypothalami were transvaginally inoculated into the uteri of syngeneic female mice. Twenty weeks later, the recipient mice were sacrificed and examined. RESULTS: Cysts, adhesion of the uteri to surrounding tissues, and adenomyosis had formed in the uteri of 7 (29.2%), 14 (58.3%), and 22 (91.7%) mice, respectively, out of 24 BALB/c mice after the transplantation of pituitary glands. Similar findings were obtained by experiments with C3H/He and C57BL/6 mice. In NK-cell-deficient C57BL/6-bgJ and T-cell-deficient BALB/c nu/nu mice, an increase in the formation of cysts, adhesion, and adenomyosis was not observed. CONCLUSIONS: These findings indicate that transvaginal pituitary transplantation specifically induces cysts, adhesion, and adenomyosis. Reduced NK-cell activities may not be necessary in the primary development of endometriosis and adenomyosis.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Disease Models, Animal Endometriosis Endometriosis Endometriosis Killer Cells, Natural Pituitary Gland Uterine Diseases Uterine Diseases Uterine Diseases Animals Female Killer Cells, Natural Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred C57BL Pituitary Gland T-Lymphocytes T-Lymphocytes Uterus

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