Down-regulation of tumor suppressor PDCD4 expression in endometrium of adenomyosis patients

Y. Liu, Liu Y, Xintong Tan, Tan X, X. Tan, Zhaoguang Wang, Z Wang, Wang Z, M Gao, Gao M, Meng Gao, Li Y, Y. Li, Fang Z, Fang Zhang, Z. Fang, Sun Y, Yawen Sun, Y Sun, L Zhang, Zhang L, Lin Zhang, X. Wang, Wang X, Z Wei, Wei Z, Zengtao Wei
Current research in translational medicine · 2016 · vol. 64(3) , pp. 123–128 · doi:10.1016/j.retram.2016.04.008 · PMID:27765271 · W2395691470
article OA: closed CC0 ⤵ 6 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-10 ⓘ

This study investigated the expression of tumor suppressor PDCD4 in the endometrium of adenomyosis patients and found that its expression was down-regulated.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

ObjectiveAdenomyosis is a common benign gynecological disease which has some malignant behaviors. Programmed cell death 4 (PDCD4) is a newly identified tumor suppressor gene which lowly expresses in various cancers. However, the expression status of PDCD4 in endometrium of adenomyosis patients has not been investigated. The aim of this study is to assess the expression levels of PDCD4 in endometrium of normal controls and adenomyosis patients.MethodsThe expression of PDCD4 in endometrium of normal controls and eutopic or ectopic endometrium of patients with adenomyosis was evaluated with quantitative real-time PCR, western blot and immunohistochemistry. In addition, the levels of serum estradiol and progesterone in normal controls and adenomyosis patients were detected using electrochemiluminescence immunoassay.ResultsThe results showed that PDCD4 mainly expressed in the cytoplasma of glandular epithelium of control endometrium and varied during the cycle changes of endometrium, which may be regulated by changing concentrations of progesterone in the menstrual cycle. Compared with the proliferative phase of control endometrium, PDCD4 expression was down-regulated in proliferative phase of eutopic endometrium or ectopic endometrium, and there was no cyclic variation of PDCD4 expression in eutopic endometrium of adenomyosis patients due to progesterone resistance.ConclusionThese results suggest that PDCD4 may be involved in the pathogenesis of adenomyosis, which will provide a novel strategy for the early diagnosis and new therapeutic target of adenomyosis.

My notes (saved in your browser only)

Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Apoptosis Regulatory Proteins Endometrium Gene Expression Regulation RNA-Binding Proteins Adenomyosis Adenomyosis Adenomyosis Adult Apoptosis Regulatory Proteins Apoptosis Regulatory Proteins Choristoma Choristoma Choristoma Cytoplasm Cytoplasm Down-Regulation Endometrium Estradiol Estradiol

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (35)

Cited by (6)

Source provenance

europepmc
last seen: 2026-08-17T06:11:01.428247+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:20:49.724109+00:00
unpaywall
last seen: 2026-08-17T06:25:09.426038+00:00
License: CC0 · commercial use OK